RIPK3

(redirected from RIP-like protein kinase 3)

RIPK3

A gene on chromosome 14q11.2 that encodes a serine/threonine/ tyrosine kinase essential for cellular necroptosis in response to the TNF-alpha family of death-inducing cytokines. RIPK3 interacts with and phosphorylates RIPK1 to form a necrosis-inducing complex, binding to and enhancing the activity of GLUL, GLUD1 and PYGL (metabolic enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation), thereby increasing reactive oxygen species production.