RIPK3

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RIPK3

A gene on chromosome 14q11.2 that encodes a serine/threonine/ tyrosine kinase essential for cellular necroptosis in response to the TNF-alpha family of death-inducing cytokines. RIPK3 interacts with and phosphorylates RIPK1 to form a necrosis-inducing complex, binding to and enhancing the activity of GLUL, GLUD1 and PYGL (metabolic enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation), thereby increasing reactive oxygen species production.
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a drug discovery and development company, today announced that it has identified a new novel gene, RIP-3, that can mediate key biological functions that can cause a cellular progression to cancer and inflammatory diseases.
The discovery of RIP-3 will enable Rigel to further develop small molecules that can regulate these disease pathways.
The RIP-3 discovery was made using Rigel's two-hybrid technology, which is able to very rapidly screen large quantities of genes of interest to determine which ones elicit biochemical interactions that cause desired changes within the context of the complete cell signaling pathway.