RET


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Ret

(ret),
Oncogene product defective in multiple endocrine neoplasia types IIA and IIB and Hirschsprung disease. It belongs to that class of membrane receptors with tyrosine kinase activity.

RET

abbreviation for rational emotive therapy.

RET

A gene on chromosome 10q11.2 that encodes a receptor for tyrosine-protein kinase involved in various cellular processes, including cell proliferation and migration, neuronal navigation and cell differentiation, upon binding with glial-cell-derived neurotrophic factor family ligands. RET regulates cell death/survival, balance and positional information. It orchestrates molecular cascades during intestinal, gut neuroendocrine, gut MALT and renal organogenesis, and it modulates cell adhesion by cleaving caspase in sympathetic neurons and mediates cell migration in an integrin (e.g., ITGB1 and ITGB3)-dependent manner. RET triggers apoptosis by intracellular caspase cleavage; it promotes survival and downregulates growth hormone production, but triggers apoptosis in absence of GDNF.

Molecular pathology
RET mutations are associated with  neuroendocrine cancers, which are characterised by defects in integrin-regulated cell migration.

RET

Abbrev. for rearranged during TRANSFECTION.

retinoscopy (ret) 

The determination of the refractive state of the eye by means of a retinoscope. Syn. skiascopy; shadow test. See chromoretinoscopy.
dynamic retinoscopy Retinoscopy performed with the patient fixating binocularly a near object such as a letter, a word, or a picture mounted on, or held close to, the retinoscope and wearing the distance correction. No working distance lens power is subtracted or added to the finding since the plane of regard is at the same distance as the retinoscope. Syn. book retinoscopy (this term is restricted to the case when the patient is reading a text); cognitive retinoscopy (when the patient fixates a single letter or reads some words); near point retinoscopy. See lag of accommodation; objective accommodation; MEM retinoscopy; Mohindra's technique of retinoscopy; static retinoscopy.
MEM retinoscopy A type of dynamic retinoscopy in which the retinoscope is held in the same plane as the near fixation target and lenses are interposed very briefly in front of one eye, while the other eye fixates the target. The aim of the method is to estimate the fundus reflex motion without disturbing the accommodative stance, that is, by leaving each lens in front of one eye for less than one second, until the neutral point is achieved. The results in non-presbyopic subjects generally show a lag of accommodation of 0 to +0.75 D. Note: MEM is an acronym of 'monocular estimate method'.
Mohindra's technique of retinoscopy Retinoscopy performed in a darkened room at 50 cm (20 inches) with the patient fixating the retinoscope light monocularly (the other eye being occluded). Distance retinoscopic refraction is derived by adding −1.00 D (to take into account the working distance and the state of accommodation in the dark) to the value found by near retinoscopy. The technique is used in paediatric optometry. Syn. monocular near retinoscopy. See resting state of accommodation; dynamic retinoscopy; MEM retinoscopy.
near point retinoscopy See dynamic retinoscopy; Mohindra's technique of.
static retinoscopy Retinoscopy performed with the patient fixating a target at distance or with accommodation paralysed.
References in periodicals archive ?
Examining the RET mutation in papillary carcinoma, Sugg et al.
RET Nuclear Expression as an Independent Predictor of Postoperative Metastasis.
Ret and trk proto-oncogene activation in thyroid papillary carcinomas in French patients from the Champagne-Ardenne region.
Activating mutations of RET appear to be of the order of 1:500 000 in the general population.
Samples with pathogenic mutations in RET exon 15 were not available for this study; therefore, only cell lines with the wild-type sequence or the codon 904 polymorphism were tested (Fig.
The plan, he said, would be to build two RETs on the west and east sides of primary runway 06/24 but revisions on the design still have to be made based on recommendations of the Civil Aviation Authority of the Philippines.
The mutation identified in this study produces a truncated RET containing the extracellular domain and part of the TMD, but not the TK, domain.
The phase 2 NSCLC trial is designed to enroll 25 patients with KIF5B/RET or related variant RET fusions in their tumors.
RET Capital, based in San Francisco, currently owns utility-scale solar energy plants in Ontario, California, and Georgia.
The study has demonstrated that patients with ASCL1 tumours with high levels of the RET oncogene protein did not survive as long as ASCL1 patients with low levels of RET.
ING UK RET said that shareholders accepting the offer are Laxey Partners with 35.
The RET protooncogene is expressed in human tissues of neural crest origin and has been recognized as a susceptibility gene for several autosomal inherited diseases, such as the multiple endocrine neoplasia type 2 syndromes, familial medullary thyroid carcinoma, and Hirschsprung disease (HSCR) (1).