Rosai-Dorfman disease

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si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

a chronic disease occurring in children and characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.

Rosai-Dorfman disease

(rō′zī-dôrf′măn′, -mən)
n.
A chronic disease characterized by painless, massively enlarged cervical lymph nodes whose sinuses contain histiocytes that have engulfed lymphocytes and other cells. Extranodal involvement sometimes occurs.

Rosai-Dorfman disease

A rare, benign idiopathic condition characterised by bilateral cervical lymphadenopathy. It is most common in young black men and women, but may affect other ages and races; it may be extranodal. 

Clinical findings
Massive bilateral cervical lymphadenopathy, fever.

Lab
Leukocytosis, increased erythrocyte sedimentation rate, polyclonal hyperimmunoglobulinaemia.
 
Prognosis
Uncertain; most resolve spontaneously, but some are aggressive and ultimately fatal.

si·nus his·ti·o·cy·to·sis with mas·sive lym·phad·e·nop·a·thy

(sī'nŭs his'tē-ō-sī-tō'sis mas'iv limf-ad-ĕ-nop'ă-thē)
A chronic disease occurring in children characterized by massive painless cervical lymphadenopathy due to distension of the lymphatic sinuses by macrophages containing ingested lymphocytes, and by capsular and pericapsular fibrosis.
Synonym(s): Rosai-Dorfman disease.

Rosai,

Juan, U.S. pathologist, 1941–.
Rosai-Dorfman disease - Synonym(s): sinus histiocytosis with massive lymphadenopathy
References in periodicals archive ?
The etiology and pathogenesis of RDD are currently unknown, and the disease can easily be misdiagnosed.
Murad said that the PHE and RDD were playing vital role in the development of rural areas, but it became the ultimate responsibility of local people to look after their water supply, drainage and solar energy schemes.
The presence of emperipolesis, or the engulfment of lymphocytes and erythrocytes by histiocytes that express S-100, is considered diagnostic of RDD.
Secretary PHE and RDD Imran Atta Soomro said that PHE construct schemes and then handover to the concerned community.
RDD is a disease whose status is largely relegated to an intriguing intellectual curiosity.
The report provides brief overview of RDD Pharma Ltd.
1) RDD is of unknown etiology, although viral agents such as human herpes virus-6 and Epstein-Barr virus are proposed to have a causative role.
A definite diagnosis of RDD requires histopathological and immunohistochemical confirmation.
These immunohistochemical findings, in conjunction with the morphologic features, are diagnostic for RDD of the colon and regional lymph nodes.
Cleanup cost after an RDD attack could range from less than a billion dollars to tens of billions of dollars, depending on area contaminated, decontamination technologies used, and level of cleanup required.
Recommendation: To better prepare federal agencies to coordinate with state and local governments on the analysis and environmental cleanup of areas contaminated with radioactive materials following RDD or IND incidents, the Secretary of Homeland Security should direct the Federal Emergency Management Agency Administrator to prepare a national disaster recovery strategy that would clarify federal responsibilities for assisting state and local governments with the analysis and environmental cleanup of areas contaminated with radioactive materials in the event of RDD or IND incidents.
In the comparison between the two depressed subgroups, RDD patients rated less olfactory stimuli as pleasant, compared with the BP group, which was the only significant difference.