RB1


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RB1

A gene on chromosome 13q14.2 that encodes a tumour suppressor protein which is a key regulator of entry into cell division, promoting G0-G1 transition following phosphorylation by CDK3/cyclin-C. RB1 represses transcription of E2F1 target genes. Underphosphorylated,
active forms of RB1 interact with E2F1 and repress its transcription activity, leading to cell cycle arrest. With calcium influx, RB1 is dephosphorylated by calcineurin, leading to release of the repressor complex.  

Molecular pathology
Defects in RB1 cause childhood retinoblastoma, some forms of osteogenic sarcoma and increased susceptibility to bladder cancer.
References in periodicals archive ?
WT 9% KRAS 25% GNAS 24% RB1 6% APC 15% MET 6% Other 15% (C), Low-grade/well-differentiated mucinous adenocarcinoma with PMP; WT 14% KRAS 43% GNAS 22% TP53 14% RB1 6% (D), appendiceal adenocarcinomas with and without goblet cell/signet ring cell features.
This study linked the RB1 mutation to abnormal activity of other genes linked to cancer without changing the makeup of the genes themselves.
Investigators found that when Pten, Tp53 and RB1 were all silenced, mice quickly developed high-grade gliomas.
Dimaras and coworkers (24) recently have shown that both copies of the retinoblastoma RB1 gene are lost or inactivated in retinoma/retinocytoma.
When a family history is present, 50% of offspring of a parent carrying an RB1 mutant allele will inherit that allele; 40% of them will develop retinoblastoma tumors.
Structural alterations of the RB1 gene in human soft tissue sarcomas.
Nominal fee required for export of RB1 soundtrack to compensate music licensors for expanded use.
In the human retina, however, p107 is almost completely inactive, leaving RB1 to do most of the work.
If your sense of adventure leads you to a different city, local hot spot or favorite off-road site, Chrysler Group's new RB1 Navigation Radio can take you there quickly, safely and accurately no matter where you are headed in the United States.
VGI has developed sequence-based DNA tests for Class 1 and 2 HLA, important for tissue typing in bone marrow transplants; RB1 associated with retinoblastoma, an eye cancer in children; p53 associated with secondary solid tumors in many cancers; Human Papilloma Virus (HPV) a pathogen believed to be a cause of cervical cancer; and drug resistance genotyping for Human Immunodeficiency Virus (HIV), the virus that causes AIDS.
has CLIP based kits in development for p53, RB1 and other cancer related
We also recorded revenues of $22,000 for the RB1 tests used during clinical trials of the RB1 GeneKit.