RB gene


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Related to RB gene: retinoblastoma, p53, Retinoblastoma 1

RB gene

Tumor suppressor gene encoding for the retinoblastoma (RB) protein, mutations of which are associated with various human tumors, including retinoblastoma, osteosarcoma, some leukemias, and some adenocarcinomas.
See: tumor suppressor gene; retinoblastoma
See also: gene
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References in periodicals archive ?
Later in the disease, something happens to inactivate the RB gene, he suggests.
One investigation, involving people with bladder cancer, suggests that the RB gene is involved in the progression of that disease.
His team turned to the RB gene and its protein product.
Cordon-Cardo believes the RB gene is involved in a turning point - when bladder cancer changes from a relatively benign disease to one that spreads wildly and aggressively.
Researchers still don't understand why the RB gene sometimes malfunctions.
Genetic engineers would have to devise a method of inserting a healthy RB gene into malignant cells.
Importantly, the antitumor effect of the novel RB94 gene was significantly greater than that seen for the wild type RB gene in these studies.
The human Rb gene is one of the best characterized of the tumor suppressor genes.
Canji seeks to introduce a normal human Rb gene into patients with bladder cancer cells that have genetic injuries or missing Rb genes.
According to published scientific reports, loss of function of the RB gene occurs in most cancers and may be an essential component of cancerous transformation," stated Dr.
Bucalo continued, "A previous issue with using the normal RB gene to kill cancer cells has been that cancer cells can sometimes shut down the wild type RB anti-cancer protein by phosphorylating it, rendering it inactive.