However, it has been difficult to effectively track the RB gene in breeding populations that have not been exposed to late blight inoculation.
bulbocastanum somatic hybrids may contain any or all of the four RGA/rga sequences, the PCR marker for the RB gene must be specific to RB and distinguishable from rb as well as other RGA/rga sequences.
In addition, our findings of low expression of cyclin D1 in the absence of pRb expression are in accordance with results of other investigators, (33) confirming the essential requirement of functional Rb gene
in cyclin D1 expression.
This suggests that problems with the RB gene are common for people with AML.
The RB gene, on the other hand, causes trouble when it is shut off.
Scientists discovered years ago that retinoblastoma involves the failure of a particular gene, the RB gene
, to function properly.
The RB gene
plays an important role in cell replication and in preventing cancerous cell transformation and proliferation.
Bert O'Malley stated that, "The RB gene
is a master control switch for cell division and a major regulating factor against tumor cell growth.
RB94 is a modified version of the naturally occurring RB tumor suppressor gene, which laboratory data indicates has significantly enhanced anti-tumor activity compared to the wild type RB gene
Canji is also developing an Rb gene
therapy product, which could be ready for human trials in 1996 as well.
Loss of heterozygosity and microsatellite alterations in p53 and RB genes
in adenoid cystic carcinoma of the salivary glands.