Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL
Adiponectin stimulates RANKL
and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway.
Furthermore, promotion of osteoblast differentiation reduced RANKL
expression and inhibited the ability of the cells to support osteoclast differentiation (18,19); osteoblast expression of the RANKL
/OPG ratio was much higher in less mature osteoblasts than in mature ones (19).
The osteoclastogenic molecules RANKL
and RANK are associated with periprosthetic osteolysis.
To find the proteins' role in the brain, Reiko Hanada, a member of Penninger's group, injected RANKL
into the brains of rats and mice.
Vitamin D3 augments osteoclastogenesis via vitamin D responsive element on mouse RANKL
4) PTH interacts with its receptor on the osteoblasts to increase the RANKL
Cells were cultured in [alpha]-MEM with 10% FBS supplemented with M-CSF (30 ng/mL), RANKL
(100 ng/mL), 1% L-glutamine, 1% penicillin/streptomycin, and 1% nonessential amino acids (Gibco).
Binding of RANKL
to RANK leads to the activation of signaling modules such as NF-kappa B, mitogen activated protein kinases (MAPK's), protein kinase C (PKC), Ca2+/Calcineurin/nuclear factor of activated T cells (NFAT) and phosphatidyl 3-kinase (PI3K).
After 24 h, the adherent cells were co-cultured with 100 ng/ml RANKL
and 50 ng/ml M-CSF.
is secreted by osteoblasts, bone marrow cells and lymphocytes, a process that increases in the acute deficiency of oestrogen that occurs in menopause.
Discover sales predictions for the world market and submarkets Along with revenue prediction for the overall world market, you see forecasts to 2024 for these three submarkets and their respective segments: -- Antiresorptive Drugs - Bisphosphonates - Selective Oestrogen Receptor Modulators (SERMs) - RANKL
Antibodies - Cathepsin K Inhibitors - Other antiresorptive drugs -- Anabolic Drugs - Human Recombinant Parathyroid Hormones - Anti-Sclerostin monoclonal antibodies -- Other osteoporosis treatments