RANBP1

RANBP1

A gene on chromosome 22q11.21 that encodes a protein that binds to RAN complexed with GTP, markedly increasing GTP hydrolysis by the RanGTPase-activating protein. RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
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3 GTPase- activating protein RANBP1 12 Transgelin-2 P378D2 24,609/8.
Comparison with previous gene expression analysis of CRC that used tissue from the tumor as the source of RNA revealed that 4 of our differentially upregulated genes, PSAM3, RANBP1, GCLC, and KIAA0101, had been previously identified in 2 different studies as upregulated in CRC (12,13).