SHC4

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SHC4

A gene on chromosome 15q21.1-q21.2 that encodes a signalling adapter protein which activates Ras-dependent and Ras-independent migratory pathways in melanomas. SHC4 contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1, and it interacts with MUSK and GRB2. It is highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumour cells acquire migratory competence and invasive potential.
References in periodicals archive ?
The mean interval between renal transplantation and RALP was 79.
Despite the small number of patients in our series, we have found that RALP is safe and effective in renal transplant recipients.
Twenty frozen tissue samples were randomly selected from our prostate biospecimen repository of tissues obtained from patients who had prostatectomies, with the consent of an institutional review board-approved protocol, including 10 samples of RRP and 10 samples of RALP.
4) The RIN numbers between the RALP and RRP samples were compared using the Student t test.
Samadi performs a unique RALP surgery at Mount Sinai coined the Samadi Modified Advanced Robotic Technique (SMART).
Besides, the continence rates 1 year after RALP reach over 90 percent in most of the large, single-centre prospective studies - results at least comparable to the open radical retropubic prostatectomy (RRP).
Hospitals are losing money on every RALP, but are still purchasing the da Vinci robots because "Patients are really pushing this technology," Dr.
Postoperative PSA surveillance with according therapeutic/diagnostic actions Time post RALP PSA (ng/mlL) Therapeutic/diagnostic (months) action 3 0.
Samadi and his colleagues sought to define specific factors impacting patient decisional regret following RALP for localized prostate cancer.
Samadi's 1 surgeon-1 team-1 procedure approach; he and his dedicated team perform one RALP at a time from start-to-finish
Despite insufficient evidence demonstrating the superiority of LRP or RALP over the gold standard (ORP), many patients choose minimally-invasive procedures based upon their perceptions of outcomes and published lay and medical literature.
Since the acquisition of the 2 daVinci S systems in September 2007 in the Capital Health Region (Edmonton, AB), until March 2009, 481 patients underwent radical prostatectomy with 371 (77%) selecting RALP.