ALDH1A3

(redirected from RALDH3)

ALDH1A3

A gene on chromosome 15q26.3 that encodes an aldehyde dehydrogenase that plays a major role in detoxifying aldehydes generated by alcohol metabolism and lipid peroxidation, either in a free or cellular retinol-binding protein form.
References in periodicals archive ?
atRA is a pleiotropic, paracrine or autocrine signaling molecule produced from vitamin A through oxidative reactions carried out by the cytosolic retinaldehyde dehydrogenases RALDHl, RALDH2, and RALDH3 (Duester 2008).
However, we show that an atRA signal generated through the activity of RALDH3 in the nasal epithelium and transduced by RARG in the nasal mesenchyme is mandatory to enable TCDD to induce cleft palate when administered at gestation day (GD) 10.
During this period of development, RALDH3 is the sole RA-synthesizing enzyme expressed in the nasopalatal region as assessed by in situ hybridization (Figure 4A) and by the complete disappearance of Tg(RARE-Hspalb/lacZ)l2Jrt activity in [Aldhla3.
AHR expression depends on RALDH3 in the frontonasal region.
mutants are resistant to TCDD-induced clefts, our study provides evidence that a functional, intact atRA signal originating from RALDH3, which is the sole atRA-synthesizing enzyme expressed in the palatal region and mediated by RARG in the facial mesenchyme, is required for TCDD to exert teratogenic effects on palate development.