ALDH1A2

(redirected from RALDH2)

ALDH1A2

A gene on chromosome 15q21.3 that encodes an aldehyde dehydrogenase which catalyses the synthesis of retinoic acid (RA) from retinaldehyde.
References in periodicals archive ?
RALDH2 is mainly present in the basal and spinous layers of the mouse dermis as well as the outer root sheath and the sebaceous glands [26].
atRA is a pleiotropic, paracrine or autocrine signaling molecule produced from vitamin A through oxidative reactions carried out by the cytosolic retinaldehyde dehydrogenases RALDHl, RALDH2, and RALDH3 (Duester 2008).
2003) because DRE have been identified in Aldhla2gene coding for RALDH2, the most potent atRA synthesizing enzyme (Wang et al.
On the other hand, more of the molecule RALDH2 protected embryos from the negative effects of alcohol.
The research provides evidence that alcohol 'hijacks' RALDH2 molecules for its own breakdown process, and steals it away from its important role in synthesizing positional and maturation cues during development.
2003; Abbreviations: AFP, [alpha]-fetoprotein; AhR, aryl hydrocarbon receptor; BMP4, bone morphogenetic protein 4; EGFR, epidermal growth factor receptor; ER[alpha], estrogen receptor-[alpha]; L-myc, lung associated myc oncogene; PPAR[gamma], peroxisome proliferator--activated receptor [gamma], RALDH2, retinal dehydrogenase 2; [T.