RAD18

RAD18

A gene on chromosome 3p25-p24 that is highly similar to the Saccharomyces cerevisiae DNA damage repair protein Rad18; it interacts with the human homologue of the yeast Rad6 protein via a conserved RING finger motif.

Molecular pathology
Mutation of the RING finger motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
References in periodicals archive ?
Several DNA repair genes, MSH2, RAD18, RAD51, RAD54, XRCC1, XRCC4, and XRCC5, and two apoptosis inducers, CASP3 and HCS, were also in this category.