lipoic acid

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li·po·ic ac·id

(li-pō'ik as'id),
A bacterial growth factor present in yeast and liver extracts; may be useful in the treatment of mushroom poisoning. Functions as the amide (lipoamide) cofactor in the disulfide (-S-S-) form in the transfer of "active aldehyde" (acetyl), the two-carbon fragment resulting from decarboxylation of pyruvate from α-hydroxyethylthiamin pyrophosphate to acetyl-CoA, itself being reduced to the dithiol form (that is, dihydrolipoic acid) in the process. Lipoic acid is also an essential component of other α-keto acid dehydrogenase complexes.

lipoic acid

/lipo·ic ac·id/ (lip-o´ik) a necessary cofactor for several enzyme complexes involved in the oxidative decarboxylation of keto acids, where it occurs in the form lipoamide. It is used as a dietary supplement for its antioxidant properties.

lipoic acid

(lĭ-pō′ĭk)
n.
An organic acid, C8H14S2O2, that is essential for decarboxylation of pyruvate to acetyl coenzyme A during aerobic metabolism. It is also used as a dietary supplement for its antioxidant properties.

lipoic acid

[lipō′ik]
a bacterial growth factor found in liver and yeast.

lipoic acid

a vitamin prosthetic group in enzymes involved in oxidative decarboxylation of keto acids such as 2-oxoglutarate and pyruvate. Called also α-lipoic acid, thioctic acid.
References in periodicals archive ?
R-lipoic acid and vitamin C decline in cells with aging and oral supplementation with R-lipoic acid in old rats improved mitochondrial function, decreased oxidative damage, and reversed the age-associated effects on vitamin C concentration.
35) R-lipoic acid is relatively unstable and tends to polymerize, whereas the sodium salt, sodium R-lipoate, is much less prone to polymerize and it displays higher plasma concentrations in humans.
Purified R-lipoic acid is highly unstable, degrading with exposure to light, air and temperatures slightly above ambient, affecting both potency and bioavailability.
In addition, animals supplemented with R-lipoic acid age more slowly than they otherwise would.
Due to these abilities, R-lipoic acid is emerging as a popular anti-aging supplement.
A dose of pure R-lipoic acid provides twice the active ingredient as a typical R/S-alpha lipoic acid supplement, simply because the whole dose consists of the active "R" molecule.
Nutrient Typical Daily Dose Pyrroloquinoline quinone (PQQ) 10-20 mg CoQ10 100-200 mg R-lipoic acid 300-600 mg Trans-resveratrol 250 mg Acetyl-L-carnitine 1,000-2,000 mg
These include quercetin, curcumin, R-lipoic acid, and milk thistle.
95) This translates into 900 mg of the biologically active R-lipoic acid.
A dramatic new study has unveiled an advanced new formulation of lipoic acid called sodium-R-lipoic acid, which is more potent and stable than pure R-lipoic acid.
This is the form of R-lipoic acid that is most readily available to cells and tissues as it does not need to undergo any chemical reduction in the body.
10) The dose of R-lipoic acid to achieve this effect in diabetics would be half this amount, since it is the "R" form of lipoic acid that is biologically active in the body.