Refluxing of compound 1 and thiourea in absolute ethanol with a catalytic amount of potassium hydroxide furnished quinazoline
thione derivative 9 in a good yield.
Pfizer with Quinazoline
currently in Phase I clinical trials.
In particular, peganine and deoxypeganine, two quinazoline
alkaloids, have a strong anticholinesterase activity (Frison et al.
alata leaves and from several studies that implicated the phytochemical property of colchicine, quinazoline
The leaves of the plant contain an essential oil and the quinazoline
alkaloids vasicine, vasicinone and deoxyvasicine.
Under the terms of this agreement (financial details were not disclosed), BTG has obtained exclusive worldwide rights to a series of novel quinazoline
anti-tumor agents developed by Professor Ann Jackman and colleagues at The Institute of Cancer Research.
anhydroacetyl-orthamidobenzamide (OED quinazoline
Comparative Study of the Vasodilatory Effects of Three Quinazoline
Alkaloids Isolated from Evodia rutaecarpa, J.
The book contains six chapters covering synthesis, reactions and applications in the following subject areas: pyridazines, cinnolines, benzocinnolines and phthalazines; pyrimidines and quinazolines
; pyrazines and related ring structures; phenzine, oxazine, thiazine and sulphur dyes; quinazoline
alkaloids; six-membered rings with three or more hetero-atoms.
Through the development of new technologies and upholding the idea of "Be environment-friendly, efficient and energy-saving," we have successfully developed a series of products, including fluoro-pharmaceutical intermediates, trivalent chromium reagents, quinazoline
series and others.
CUDC-101, a small organic molecule of the quinazoline
class, inhibits several clinically and commercially validated cancer targets at the same time.
FSMA began the Quinazoline
program in 2000 at the very initial stages of drug development, when risk is the highest.