Questran


Also found in: Dictionary.
Related to Questran: Questran Light

cholestyramine

LoCHOLEST, LoCHOLEST Light, Novo-Cholamine (CA), Novo-Cholamine Light (CA), Prevalite, Questran,Questran Light

Pharmacologic class: Bile acid sequestrant

Therapeutic class: Lipid-lowering agent

Pregnancy risk category C

Action

Combines with bile acid in GI tract to form insoluble complex excreted in feces. Complex regulates and increases cholesterol synthesis, thereby decreasing serum cholesterol and low-density lipoprotein levels.

Availability

Powder for suspension; powder for suspension with aspartame: 4 g cholestyramine/packet or scoop

Indications and dosages

Primary hypercholesterolemia and pruritus caused by biliary obstruction; primary hyperlipidemia

Adults: Initially, 4 g P.O. once or twice daily. May increase as needed and tolerated, up to 24 g/day in six divided doses.

Off-label uses

• Antibiotic-induced pseudomembranous colitis
• Adjunct in infantile diarrhea
• Digoxin toxicity

Contraindications

• Hypersensitivity to drug, its components, or other bile-acid sequestering resins
• Complete biliary obstruction
• Phenylketonuria (suspension containing aspartame)

Precautions

Use cautiously in:
• history of constipation or abnormal intestinal function
• pregnant patients
• children.

Administration

• Mix powder with soup, cereal, pulpy fruit, juice, milk, or water.
• Administer 1 hour before or 4 to 6 hours after other drugs.
• Be aware that fat-soluble vitamin supplements may be necessary with long-term drug use.

Adverse reactions

CNS: headache, anxiety, vertigo, dizziness, insomnia, fatigue, syncope

EENT: tinnitus

GI: nausea, vomiting, constipation, abdominal discomfort, fecal impaction, flatulence, hemorrhoids, perianal irritation, steatorrhea

GU: hematuria, dysuria, diuresis, burnt odor to urine

Hematologic: anemia, ecchymosis

Hepatic: hepatic dysfunction

Metabolic: vitamin A, D, E, and K deficiencies; hyperchloremic acidosis

Musculoskeletal: joint pain, arthritis, back pain, muscle pain

Respiratory: wheezing, asthma

Skin: hypersensitivity reaction (irritation, rash, urticaria)

Other: tongue irritation

Interactions

Drug-drug.Acetaminophen, amiodarone, clindamycin, clofibrate, corticosteroids, digoxin, diuretics, fat-soluble vitamins (A, D, E, and K), gemfibrozil, glipizide, imipramine, methotrexate, methyldopa, mycophenolate, niacin, nonsteroidal anti-inflammatory drugs, penicillin, phenytoin, phosphates, propranolol, tetracyclines, tolbutamide, thyroid preparations, ursodiol, warfarin: decreased absorption and effects of these drugs

Drug-diagnostic tests.Alkaline phosphatase: increased level

Hemoglobin: decreased value

Prothrombin time: increased

Patient monitoring

• Monitor CBC with white cell differential and liver function test results.
• If bleeding or bruising occurs, monitor prothrombin time. Drug may reduce vitamin K absorption.
• Watch for constipation, especially in patients with coronary artery disease. Take appropriate steps to prevent this problem.

Patient teaching

Instruct patient to immediately report yellowing of skin or eyes or easy bruising or bleeding.
• Tell patient to take drug 1 hour before or 4 to 6 hours after other drugs.
• Teach patient about role of diet in controlling cholesterol level and preventing constipation.
• Instruct patient to avoid inhaling or ingesting raw powder. Tell him to mix powder with food, juice, or milk before consuming.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Questran

(kwĕs′trən)
A trademark for the drug cholestyramine.

Questran

a trademark for an ion exchange resin used to lower blood cholesterol levels (cholestyramine resin).

Cholestyramine (Questran)

A drug used to bind with bile acids and prevent their reabsorption and to stimulate fat absorption.
References in periodicals archive ?
Included among these products are the well-known Bristol Myers Squibb brands: Bufferin, Capoten, Duracef, Kenalog, Mycostatin, Questran, and Velosef.
27 /PRNewswire/ -- Bristol-Myers Squibb Company today announced that as a precautionary measure, it is voluntarily withdrawing Questran Tablets (Cholestyramine Tablets) from the U.
Questran Tablets (Cholestyramine Tablets) will be available, for physician prescribing within the next several weeks.
Questran Tablets complement the existing Questran and Questran Light powders and provide a more convenient dosing regimen, which may enhance patient compliance.
Questran Tablets provide a welcome alternative for current users of Questran and Questran Light who may have experienced difficulty with compliance over a prolonged period of time," said Sam Barker, Ph.
Questran Tablets are indicated as an adjunct to diet for the reduction of elevated cholesterol in patients with primary hypercholesterolemia who do not respond adequately to diet alone.
Of the 17 cardiovascular products the company makes, the major products included under the new program are Capoten(R), an ACE (angiotensin-converting enzyme) inhibitor used in the treatment of hypertension and in the treatment of heart failure; Monopril(R), an ACE inhibitor used to treat mild to moderate hypertension; Pravachol(R), an HMG-CoA reductase inhibitor used to control cholesterol; Corgard(R), a beta blocker used to control hypertension and angina pectoris, and Questran(R) and Questran Light(R), cholesterol-lowering agents(A).