Quaternary Syphilis

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Quaternary Syphilis

The fourth chronologic stage of syphilis, which may follow tertiary syphilis in immunocompromised patients, e.g., those with AIDS, and is characterised by necrotising, spirochete-laden encephalitis, variably accompanied by evidence of end-stage HIV-1-induced anergy and/or loss of cell-mediated immunity against treponemal antigens

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