In an uncontrolled ECG study in 26 patients, QT prolongation
was observed on Day 8, independent of Halaven concentration, with no prolongation on Day 1.
Reported AEs of hyperglycaemia, interstitial lung disease (ILD) and QT prolongation
remained consistent with data previously presented: ILD and pneumonitis 3% (2% ?
Food and Drug Administration published an advisory that warned of a dose-dependent risk of QT prolongation
Nadir Saoudi, from the Princess Grace Hospital Centre, Monaco, reported how excessive consumption of cola drinks can result in marked potassium loss (hypokalemia), QT prolongation
on ECGs and potentially life threatening arrhythmias.
One of the take home messages is that cardiologists need to be aware of the connection between cola consumption and potassium loss, and should ask patients found to have QT prolongation
about beverage habits," Zarqane said in a statement.
was found in four patients, AV block was found in two patients (first degree in one patient and second degree in the other patient) and ST depression was found in one patient.
The biggest culprit among SSRIs is citalopram, which explains why the Food and Drug Administration has offered detailed recommendations about the risks of QT prolongation
among patients taking that antidepressant.
Clinical studies consistently demonstrate that arsenic trioxide, used to treat acute promyelocytic leukemia, induces QT prolongation
, torsades de pointes (a life-threatening polymorphic ventricular tachycardia), and sudden death (Ohnishi et al.
FDA drug safety communication: New information regarding QT prolongation
with ondansetron (Zofran).
has issued a warning about the risk of QT prolongation
(long QT syndrome, a risk factor for heart disease)'with azithromycin.
Thus, the majority of the QT interval reflects ventricular repolarization, and QT prolongation
, predominantly, reflects delayed ventricular repolarization.
Potentially life-threatening consequences from overdose include QT prolongation
and respiratory depression.