long QT syndrome

(redirected from QT prolongation)

long QT syndrome

 
a combination of prolonged Q–T interval and torsades de pointes; it may be congenital or acquired, the latter usually being the result of drug administration.

long QT syndrome

an inherited cardiac disorder characterized by prolongation of the Q-T interval. The disorder is associated with ventricular tachycardia, cardiac arrhythmias, syncope, and sudden death. Syncopal episodes often occur during physical exercise in young, otherwise healthy persons. This syndrome may also be caused by a variety of drugs.

prolonged QT syndrome

, long QT syndrome, QT syndrome
A life-threatening syndrome marked by a prolonged Q-T interval with episodes of electrocardiographic torsades de pointes. This condition may be inherited or may be acquired as a result of drug administration. Inherited variants of the long QT syndrome include Romano-Ward syndrome and Lange-Nielsen syndrome. It is treated with beta-blocking drugs or an implanted cardioverter defibrillator (ICD).
References in periodicals archive ?
In an uncontrolled ECG study in 26 patients, QT prolongation was observed on Day 8, independent of Halaven concentration, with no prolongation on Day 1.
Reported AEs of hyperglycaemia, interstitial lung disease (ILD) and QT prolongation remained consistent with data previously presented: ILD and pneumonitis 3% (2% ?
Food and Drug Administration published an advisory that warned of a dose-dependent risk of QT prolongation with citalopram.
Nadir Saoudi, from the Princess Grace Hospital Centre, Monaco, reported how excessive consumption of cola drinks can result in marked potassium loss (hypokalemia), QT prolongation on ECGs and potentially life threatening arrhythmias.
One of the take home messages is that cardiologists need to be aware of the connection between cola consumption and potassium loss, and should ask patients found to have QT prolongation about beverage habits," Zarqane said in a statement.
QT prolongation was found in four patients, AV block was found in two patients (first degree in one patient and second degree in the other patient) and ST depression was found in one patient.
The biggest culprit among SSRIs is citalopram, which explains why the Food and Drug Administration has offered detailed recommendations about the risks of QT prolongation among patients taking that antidepressant.
Clinical studies consistently demonstrate that arsenic trioxide, used to treat acute promyelocytic leukemia, induces QT prolongation, torsades de pointes (a life-threatening polymorphic ventricular tachycardia), and sudden death (Ohnishi et al.
FDA drug safety communication: New information regarding QT prolongation with ondansetron (Zofran).
has issued a warning about the risk of QT prolongation (long QT syndrome, a risk factor for heart disease)'with azithromycin.
Thus, the majority of the QT interval reflects ventricular repolarization, and QT prolongation, predominantly, reflects delayed ventricular repolarization.
Potentially life-threatening consequences from overdose include QT prolongation and respiratory depression.