KAT6B

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KAT6B

A gene on chromosome 10q22.2 that encodes a histone acetyltransferase which, depending on the context, up- or downregulates transcription. KAT6B is required for RUNX2-dependent transcriptional activation and may be involved in development of the cerebral cortex. It is part of the MOZ/MORF complex, which has histone H3 acetyltransferase activity.

Molecular pathology
Defects in KAT6B are a cause of genitopatellar syndrome and Ohdo syndrome (SBBYS variant). Chromosomal defects  of KAT6B have been linked to acute myeloid leukaemias via translocation t(10;16)(q22;p13) with CREBBP.
References in periodicals archive ?
Michael Katz, Executive Vice-President of QKF said, "I look forward to the exciting opportunities for QKF and its suppliers that buying for the three entities will present.
Subject to the terms of the definitive purchasing agreement, QKF will make available 60-day credit terms on purchases of fragrances up to ECOM V's approved credit limit .
Glenn and Stephen Nussdorf together own a majority interest in the parent of QKF and Scents of Worth, Inc.