pyruvate dehydrogenase (lipoamide)
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py·ru·vate de·hy·dro·gen·ase (lip·o·am·ide)
an oxidoreductase catalyzing conversion of pyruvate and (oxidized) lipoamide to CO2 and S6-acetyldihydrolipoamide in two successive reactions: the first between pyruvate and thiamin pyrophosphate to yield CO2 and α-hydroxyethylthiamin pyrophosphate (active pyruvate); the second between the last named and lipoamide to regain the thiamin pyrophosphate and yield S6-acetylhydrolipoamide. Compare: α-ketodecarboxylase.