pyroglutamic acid

(redirected from Pyroglutamate)

5-ox·o·pro·line (Glp),

(ok'kō-prō'lēn),
A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and γ-glutamylated peptides; it is also produced by the action of γ-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.

pyroglutamic acid

[pi′roglootam′ik]
an uncommon amino acid derivative.

pyroglutamic acid

see 5-oxoproline.
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References in periodicals archive ?
2009) investigated the effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine.
s])-[gamma]-L-glutamyl-L- [S-(4-hydroxybenzyl)]cysteinylglycinate sulfoxide 47 (-)-[gamma]-L-[N-(4-hydroxybenzyl)]glutamyl-L- [S-(4-hydroxybenzyl)] cysteinylglycine 48 (+)-L-[S-(4-hydroxybenzyl)]cysteinylglycine 49 (+MS)-[N-(4'-hydroxybenzyl)]pyroglutamate 50 (-)-(R)-[N-(4'-hydroxybenzyl)]pyroglutamate 51 Ethyl (+)-(S)-{N-[4'-hydroxy-3'-(4"-hydroxybenzyl)benzyl]} pyroglutamate 52 Ethyl (+)-(S)-2-hydroxy-3-[(4,-hydroxybenzyl)thio]propanoate 53 (+)-(S)-2-hydroxy-3-[(4'-hydroxybenzyl)thio]propanoic acid 54 Methyl (-)-(R)-2-hydroxy-4-[(4'-hydroxybenzyl)thio]butyrate 55 Methyl (+)-(S)-2-hydroxy-3-[(4,-hydroxybenzyl)thio] propanoate Phenolic compounds containing a nucleoside 56 [N.
Glutaminyl cyclase (QC), an enzyme found in animals and plants, catalyzes the cyclization of N-terminal Glutamine, and to a lesser extent Glutamate, to pyroglutamate (1).
An antibody to an amino-terminal truncated form of A[beta] starting from pyroglutamate at position 3 may provide an interesting medical treatment because this form of A[beta] is present in human brains only under pathological conditions.
In particular, one amino acid, pyroglutamate (PCA), is a key component of Natural Moisturizing Factor and enhances blood circulation by modulating constitutive nitric oxide production.
Capping this stub is a rare, circular amino acid called pyroglutamate.
piracetam, aniracetam, fipexide, oxiracetam, pramiracetam, pyroglutamate, vinpocetine and many other new molecules in clinical trials.
Though the N-terminal pyroglutamate is found in many different peptides in virtually all species, including Drosophila, QC activity has not been observed in Drosophila.
Another study recently demonstrated that Agaricus blazei possesses a potent anti-angiogenic phytochemical, sodium pyroglutamate, which was determined to exert a triple play of actions-immune-modulatory, anti-tumor and anti-metastatic--in tumor-bearing mice.
Amyloid R protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.
91) Glycerol Contamination (suppository, Malonate (92) emollients); uremia Mevalonate and/or its lactone N-Acetylaspartate Orotate (93-95) Allopurinol treatment; azauridine; high cell turnover (tissue breakdown, menstruation); folate malabsorption Pyroglutamate (L- or From glutamine of hydrolyzed D-5-oxoproline) proteins (infant formula); (82, 91, 96-102) acetaminophen; vigabatrin; fludoxacillin, netilmicin (?