pyroglutamic acid

(redirected from Pyroglutamate)

5-ox·o·pro·line (Glp),

(ok'kō-prō'lēn),
A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and γ-glutamylated peptides; it is also produced by the action of γ-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.

pyroglutamic acid

[pi′roglootam′ik]
an uncommon amino acid derivative.

pyroglutamic acid

see 5-oxoproline.
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References in periodicals archive ?
Glutaminyl cyclase (QC), an enzyme found in animals and plants, catalyzes the cyclization of N-terminal Glutamine, and to a lesser extent Glutamate, to pyroglutamate (1).
Pyroglutamate modification sometimes may lead to negative side effects.
In particular, one amino acid, pyroglutamate (PCA), is a key component of Natural Moisturizing Factor and enhances blood circulation by modulating constitutive nitric oxide production.
Capping this stub is a rare, circular amino acid called pyroglutamate.
Though the N-terminal pyroglutamate is found in many different peptides in virtually all species, including Drosophila, QC activity has not been observed in Drosophila.
Another study recently demonstrated that Agaricus blazei possesses a potent anti-angiogenic phytochemical, sodium pyroglutamate, which was determined to exert a triple play of actions-immune-modulatory, anti-tumor and anti-metastatic--in tumor-bearing mice.
Amyloid R protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.
06/E36 - Pyroglutamate forms of beta-amyloid peptides with glutaminyl cyclase in neurotransmitter secretory vesicles: Relevance to Alzheimer's disease L.
91) Glycerol Contamination (suppository, Malonate (92) emollients); uremia Mevalonate and/or its lactone N-Acetylaspartate Orotate (93-95) Allopurinol treatment; azauridine; high cell turnover (tissue breakdown, menstruation); folate malabsorption Pyroglutamate (L- or From glutamine of hydrolyzed D-5-oxoproline) proteins (infant formula); (82, 91, 96-102) acetaminophen; vigabatrin; fludoxacillin, netilmicin (?
Other acids were also included in preliminary experiments: pyroglutamate, glycerate, p-hydroxyphenyllactate, sebacate, citrate, adipate, succinate, glutarate, and oxalate.