stabilizing selection

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Fig. 287 Stabilizing selection .

stabilizing selection

a type of SELECTION in which both extremes of a phenotypic range are selected against, producing a stable The mean represents the stable average phenotype.
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Kumar highlighted how new mutations continuously arise in our genomes and their fate is determined by the action of purifying selection, genetic drift and positive selection.
Hence, the evolutionary study of the IL-32 gene in 11 mammalian species indicated the gene was under purifying selection where previously no positive selection had been reported.
By mapping substitutions onto a gene tree of relationships among haplotypes, such models can characterize the relative contributions of purifying selection or positive Darwinian selection as the ratio of those relative rates [omega] = [d.
Selective pressure analysis demonstrated that all ZmCLO genes were under purifying selection, and no positively selected sites were found at a significant level.
Our method is a practical and successful way to screen for purifying selection in non-coding regions of the genome using freely available data such as those from the ENCODE and 1000 Genomes Projects," says Dr Yali Xue, author from the Wellcome Trust Sanger Institute.
062), which indicates stronger purifying selection on the DK-B group.
Thus, neutral mutations are the ones left over after the purifying selection filter - these are the mutations that can exist as polymorphisms with the potential to fix and contribute to divergence among species.
But comparative analysis of plant genomes also point to ancient genes, highly conserved and under strong purifying selection.
The numbers of synonymous (dS) and nonsynonymous substitutions (dN) per synonymous and non-synonymous sites, respectively, were used to calculate the test statistic (dN-dS) along with the probability of rejecting the null hypothesis that the codons have evolved through neutral selection (dN = dS), against the alternative hypothesis of evolution of the codon through positive selection (test of positive selection; dN>dS) or through purifying selection (test of purifying selection; dN<dS).
Gene evolution can be explained by the signatures of purifying selection positive selection and neutral evolution.
N] indicates past purifying selection that has eliminated deleterious nonsynonymous mutations (10).