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dornase alfa


Pharmacologic class: Recombinant human deoxyribonuclease I

Therapeutic class: Cystic fibrosis agent, mucolytic enzyme, respiratory inhalant

Pregnancy risk category B


Selectively cleaves to DNA in sputum, decreasing viscosity of pulmonary secretions


Inhalation solution: 2.5-mg ampule (1 mg/ml)

Indications and dosages

To reduce respiratory tract infections and improve pulmonary function in patients with cystic fibrosis

Adults and children: One ampule (2.5 mg) inhaled once daily; some patients may benefit from twice-daily dosing. Safety and efficacy of daily administration haven't been demonstrated for longer than 12 months.


• Hypersensitivity to drug, its components, or products derived from Chinese hamster ovary cells


Use cautiously in:
• pregnant or breastfeeding patients.


• Don't shake, dilute, or mix with other drugs.
• Use only with approved nebulizer.
• Discard cloudy or discolored solution.

Adverse reactions

CV: chest pain

EENT: conjunctivitis, rhinitis, pharyngitis, hemoptysis, voice changes

Respiratory: dyspnea, increased sputum, wheezing

Skin: rash, urticaria, pruritus

Other: hypersensitivity reactions


None known

Patient monitoring

• Assess patient periodically. Report improvement in dyspnea and sputum clearance.
• Monitor for signs and symptoms of hypersensitivity reaction.

Patient teaching

• Teach patient how to use nebulizer.
• Instruct patient to report rash, hives, and itching.
• As appropriate, review all other significant adverse reactions mentioned above.


(po͝ol′mə-zīm′, pŭl′-)
A trademark for the drug dornase alfa.


Dornase alpha solution Pulmonology A therapy for cystic fibrosis for FVC–forced expiratory volume < 40% to improve pulmonary function and ↓ RTIs requiring parenteral antibiotics. See Cystic fibrosis.


A brand name for DORNASE ALFA.
References in periodicals archive ?
We thought Pulmozyme would be more effective than NAC in liquefying the mucus, because CF sputum contains lots of DNA, said Fahy.
We have been pleased with eRapid's fast treatment times in the lab and are excited that patients now have access to a much faster Pulmozyme therapy.
Consensus conference: practical applications of Pulmozyme.
Both groups of patients given the Pulmozyme had significant reduction in the number of patients needing antibiotics for respiratory tract infections compared to the placebo group.
Continuous treatment with Pulmozyme costs about $10,000 a year, but using it improves breathing function and reduces the risk of the recurring lung infections that require hospitalization equal in cost to treatment with this new drug.
During the quarter, Genentech completed a Phase III clinical trial of Pulmozyme in early-stage cystic fibrosis.
Phase IIa clinical trial of Genentech's Pulmozyme (dornase alfa inhalation solution) using Aradigm's proprietary AERx pulmonary delivery system.
My passion for CF-related research and patient care stems from my years spent at Washington University and at Genentech, where I participated in the pre-launch, launch and post-approval activities for PULMOZYME.
develop Pulmozyme, another treatment for cystic fibrosis.
Jones held various key positions at biopharma companies, including Medimmune, where he was responsible for the launch of both Respigam and Synagis and Genentech, where he was responsible for the launch of Protropin, Activase and Pulmozyme.
Some are pills, like different antibiotics, and some are nebulizers or inhalers such as Albuterol, Pulmozyme.