psoralens


Also found in: Dictionary.
Related to psoralens: ichthyosis

psoralens (sōrˑ··lenz),

n.pl polycyclic molecules with the ability to absorb ultraviolet photons.
References in periodicals archive ?
ibuprofen, ketoprofen, piroxicam, diclofenac), cardiovascular drugs (furosemide, amiodarone, thiazides), antibiotics (tetracyclines, ciprofloxacin, sulfonamides), psoralens, neuroleptic drugs such as phenothiazines (especially chlorpromazine), oral contraceptives, retinoids (isotretinoin, acitretin), antifungals, etc.
2) There have been rare reports of photosensitivity reactions due to ingestion of large quantities of plants containing furocoumarins and psoralens.
Additional drugs that can produce phototoxic reactions include amiodarone, psoralens and phenothiazines, anticancer drugs, retinoids, zidovudine, and quinine.
Fresh grapefruit showed the most apparent association with melanoma among individual citrus products, which may be explained by its higher levels of psoralens and furocoumarins when compared with oranges," the researchers noted.
Other risk factors for melanomas include three or more blistering sunburns before age 18 years, congenital nevi, large numbers of moles, and long-term phototherapy for eczema or psoriasis with psoralens and UVA (PUVA).
Psoralens are a group of photosensitizing drugs which are ineffective when used alone, but in combination with UVR provide an effective tool for the treatment of psoriasis and a number of other photoresponsive skin disorders e.
To mitigate the side effects of systemic psoralens, PUVA-turban therapy is used for alopecia areata involving the scalp.
Using limes and synthetic psoralens to enhance solar disinfection of water (SODIS): a laboratory evaluation with norovirus, Escherichia coli, and M52.
Psoralen and UVA (PUVA), which uses oral or topical psoralens to sensitize the skin to UVA, has a slightly higher efficacy than NB-UVB, hut with increased risk of squamous cell carcinoma (SCC) and possibly melanoma.
Twenty-one healthy volunteers [either untreated or treated with oral psoralens (8-MOP or 5-MOP)] were enrolled in this study and exposed to solar radiation for evaluation of the following clinical parameters: immediate pigment darkening (IPD), minimal erythema dose (MED), minimal melanogenic dose (MMD), and minimal phototoxic dose (MPD) before and after topical or oral administration of PL.
The ancient Egyptians used a combination of plant extracts and natural sunlight to treat skin disease and a modified form of this therapy is still in use today in the form of psoralens and ultraviolet A (known as PUVA).
It can cause severe phototoxity in the presence of drugs like psoralens, doxycycline, sulfonamides, sulfonylureas and chlorthiazides.