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pseudohyperaldosteronism

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pseudohyperaldosteronism
Liddle syndrome An AD aldosteronism-like condition characterized by severe HTN and spontaneous hypokalemia
(K+ wasting) leading to hypokalemic alkalosis with ↓ aldosterone secretion Treatment KCl, amiloride and triamterene to prevent K+ wasting, sodium restriction; renal transplantation. Cf Hyperaldosteronism.
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Glycyrrhetic acid is the chief cause of licorice-induced pseudohyperaldosteronism syndrome seen with licorice ingestion, because of its inhibitory effect on the enzyme 11 beta-hydroxysteroid dehydrogenase.
Licorice Information - Side Effects, Uses and Benefits-Herbal Remedies by Robert Baird / Health, general community
8) Fluoroprednisolone and 9[alpha]-fluorocortisol have considerable direct mineralocorticoid activity; in large amounts they produce arterial hypertension with a clinical picture of pseudohyperaldosteronism (increased exchangeable sodium and blood volume, hypokalemic metabolic alkalosis, and suppressed plasma renin and aldosterone levels).
Secondary hypertension due to drugs and toxins by Gyamlani, Geeta; Geraci, Stephen A. / Southern Medical Journal
 
 
 
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