PSEN2

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PSEN2

A gene on chromosome 1q31-q42 that encodes a probable catalytic subunit of the gamma-secretase complex, which catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. It may play a role in intracellular signalling and gene expression, or in linking chromatin to the nuclear membrane; it may also play a role in sorting proteins in the cytoplasm.

Molecular pathology
Defects in PSEN2 are a cause of Alzheimer disease type 4 and cardiomyopathy dilated type 1V.
References in periodicals archive ?
Mild & Creamy Fruity Chicken with Rice (350g), Waitrose, PS2.
But that, game-industry experts contend, won't stop the PS2 from reinventing video gaming.
A Morrisons spokesman said: "A handful of stores in the West Midlands have had foreign currency passed off as PS2 coins at self checkouts.
The latest state of the art offering for the PS2 is the stunning WRC II Extreme, featuring stunning graphics and amazing sound.
Truly Irresistible Chicken & Chenin Blanc Pie (200g), Co-op, was PS2.
SAVE: PS1 |Mini Smarties Multipack | |(260g), Iceland, Were PS2.
Back in the parking lot at Target, PS2 recipient No.
Mini Chicken Satay Sticks (128g), Asda, PS2 or three for PS5 SAVE: PS1
British Cherry Punnet (250g), Sainsbury's, was PS2, now PS1.
PS2 or two for PS3 SAVE: PS1 Finest Waldorf Salad |(300g), Tesco.
SAVE: PS2 Oreo Vanilla |Flavour Ice Cream (480ml), Iceland, was PS3, now PS2.