FGF3(redirected from Proto-oncogene Int-2)
FGF3A gene on chromosome 11q13 that encodes fibroblast growth factor 3 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. FGF3 may be required for normal ear development. It interacts with FGF receptors FGFR1 and -2.
FGF3 mutations are a cause of deafness with labyrinthine aplasia, microtia and microdontia (LAMM).