thrombin

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thrombin

 [throm´bin]
1. the activated form of coagulation factor II (prothrombin), which catalyzes the conversion of fibrinogen to fibrin.
2. a preparation of this compound prepared from prothrombin of bovine origin, used as a topical hemostatic.
thrombin time (TT) the time required for plasma fibrinogen to form thrombin: exogenous thrombin is added to citrated plasma and the time to clot formation is measured. Prolonged TT is seen with abnormalities of fibrinogen and in the presence of heparin or degradation products of fibrin or fibrinogen.

throm·bin

(throm'bin),
1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.

thrombin

/throm·bin/ (throm´bin)
1. the activated form of coagulation factor II (prothrombin); it catalyzes the conversion of fibrinogen to fibrin.
2. a preparation derived from prothrombin of bovine origin together with thromboplastin and calcium; used therapeutically as a local hemostatic.

thrombin

(thrŏm′bĭn)
n.
A protease in blood that facilitates blood clotting by converting fibrinogen to fibrin.

thrombin

[throm′bin]
the key enzyme produced during coagulation by activation of prothrombin. Thrombin converts fibrinogen to fibrin, activates factors V, VIII, XI, and XIII, and causes platelet aggregation. See also blood clot , prothrombin.

thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.

throm·bin

(throm'bin)
1. An enzyme (proteinase), formed in shed blood, that converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase (factor Xa, another proteinase).
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting of whole blood, plasma, or a fibrinogen solution; used as a topical hemostatic for capillary bleeding with or without fibrin foam in general and plastic surgical procedures.
Synonym(s): factor IIa.

thrombin

An enzyme in the blood that converts fibrinogen to fibrin, thus forming a blood clot.

thrombin

see BLOOD CLOTTING.

Thrombin

Thrombin is a protein produced by the body. It is a specific clotting factor that plays an important role in the blood clotting process.

thrombin

clotting cascade enzyme, formed from prothrombin

throm·bin

(throm'bin)
1. An enzyme (proteinase), formed in shed blood, which converts fibrinogen into fibrin by hydrolyzing peptides (and amides and esters) of l-arginine; formed from prothrombin by the action of prothrombinase.
2. A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting; used as a topical hemostatic for capillary bleeding in general and plastic surgical procedures.
Synonym(s): factor IIa.

thrombin (throm´bin),

n a proteolytic enzyme formed from prothrombin by the action of thromboplastin, factor IV calcium (Ca++), and other factors. Thrombin forms fibrin from fibrinogen, speeds up the disruption of platelets, and activates factor V.

thrombin

an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets. A preparation from prothrombin of bovine origin is used as a topical hemostatic.

thrombin-thrombomodulin complex
thrombomodulin, a specific endothelial cell surface receptor, converts thrombin, a very weak activator of protein C in the anticoagulant pathway, to the status of a very active protein C activator.
thrombin time
the time required for a standardized solution of thrombin to clot plasma. It is a measure of the rate of conversion of fibrinogen to fibrin.
References in periodicals archive ?
Hunter-Mellado, which describes three patients with Factor V Leiden mutation, two of which patients were found to have the prothrombin G20210A mutation (7).
While the prothrombin G20210A mutation is linked to elevations in prothrombin, measuring prothrombin levels is not an accurate way to test for this hypercoagulable state.
The factor V Leiden mutation occurs in about 5% of the Caucasian population (ie, Europeans, Jews, Israeli Arabs, and Indians), and the prothrombin G20210A mutation occurs in about 2%.
However, they did find an increased risk of recurrent DVT in carriers of both the FVL and prothrombin G20210A mutations.
The FV Arg506G1n and prothrombin G20210A mutations were identified as described previously (22).
To date, this concept has been tested in some groups known to have increased risk of thrombosis, such as women on oral contraceptives (79), patients with the prothrombin G20210A mutation (80), and patients treated with oral anticoagulants or heparin (81).
the prothrombin G20210A mutation and possibly the methylene tetrahydrofolate reductase (MTHFR) C677T mutation (24-26).
We have used this high-speed mutation detection successfully for the identification of the apolipoprotein E isoforms, the apolipoprotein B3500 mutation, the prothrombin G20210A mutation, and the C677T mutation in methylenetetrahydrofolate reductase (7, 8).
Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages.
Thrombosis in children with cardiac pathology: frequency of factor V Leiden and prothrombin G20210A mutations.

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