prothrombin complex concentrate

(redirected from Prothrombin complex)


1. to bring to a common center; to gather at one point.
2. to increase the strength by diminishing the bulk of, as of a liquid; to condense.
3. a drug or other preparation that has been strengthened by evaporation of its nonactive parts.
activated prothrombin complex concentrate (APCC) anti-inhibitor coagulant complex.
prothrombin complex concentrate (PCC) factor IX complex.

prothrombin complex concentrate (PCC)

prothrombin complex concentrate

Hematology Any commercial product–eg, FEIBA–Factor VIII inhibitor by-passing activity that contain nonactivated factors IX, in addition to II, XI and X; PCCs may be used to ameliorate the intensity and duration of joint and soft tissue bleeding in hemophiliacs who produce factor VIII inhibitors; PCCs are 50% effective in staunching hemorrhage. See Prothrombin.
References in periodicals archive ?
At the same time, the supply and R & D capabilities of human blood coagulation factor VIII, human prothrombin complex and other small products in rigid demand have been intensified in recent years.
Part 3 Activated prothrombin complex concentrate (coagulation factor VIII inhibitor "bypassing" preparation activity.
It covers critical care indications that are being treated using the five major plasma-derived products of albumin, anti-thrombin concentrates, factor XIII concentrates, fibrinogen concentrates, and prothrombin complex concentrates.
Treatment strategies to control active bleeding include the use of factor VIII concentrates, activated prothrombin complex concentrates (anti-inhibitor coagulant complex, Feiba, Autoplex T), and recombinant human factor VIIa (6), (8), (9).
Use of procoagulant reversal agents such as prothrombin complex concentrate (PCC), activated prothrombin complex concentrate (APCC), or recombinant factor VIIa (rFVIIa) may be considered, but has not been evaluated in clinical trials.
FVII can be temporarily supplemented by infusing fresh frozen plasma, prothrombin complex concentrates containing factors X, IX, VII, and II derived from plasma, and recombinant FVIIa (NovoSeven[R]).
he received blood products, DDAVP, prothrombin complex concentrate, and aminocaproic acid.
1] every 12 hours and give fresh plasma transfusion or prothrombin complex concentrate as needed.
New York, NY) has patented a method for activating prothrombin to thrombin in a prothrombin complex composition comprising at least prothrombin, Factors V, VII, IX, and X, and phospholipid, comprising the steps of: (a) cold-incubating the prothrombin complex composition with 2-15 mM of Ca2+ ions at a pH of 6.
blood-clotting proteins recombinant Factor VIIa, 3- or 4-factor prothrombin complex concentrates (PCC), and activated PCC].
Patients with the disorder are usually treated with fresh-frozen plasma or plasma-derived prothrombin complex concentrates (plasma products containing a combination of vitamin K-dependent proteins) to stop or prevent bleeding.
Beriplex(R) P/N, a human prothrombin complex concentrate (PCC), is highly effective and safe in the emergency reversal of anti-coagulation according to data presented today at the International Society on Thrombosis and Haemostasis (ISTH) XXIst Congress.

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