protease

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Related to Proteolytic cleavage: glycosylation, proteinases

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

pro·te·ase

(prō'tē-āz),
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (break) polypeptide chains.

protease

/pro·te·ase/ (pro´te-ās) endopeptidase.

protease

(prō′tē-ās′, -āz′)
n.
Any of various enzymes, including the endopeptidases and exopeptidases, that catalyze the hydrolytic breakdown of proteins. Also called peptidase.

protease

[prō′tē·ās]
an enzyme that is a catalyst in the breakdown of peptide bonds that join the amino acids in a protein. See also proteolysis.

pro·te·ase

(prō'tē-ās)
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (i.e., break) polypeptide chains.

protease

One of a range of protein-splitting enzymes. One focus of current interest in proteases is in their role in breaking down tissue barriers in the spread of cancer. High concentrations of the activator of one of these proteases has been found to be associated with a poor outlook in cancers of the colon and rectum.

protease

any enzyme that splits proteins, such as PEPSIN, TRYPSIN, EREPSIN or RENNIN.

protease

; proteinase enzyme that breaks down/proteolyses protein

protease

any proteolytic enzyme.

protease-antiprotease imbalance
thought to play a part in the pathogenesis of emphysema by permitting excessive proteolysis, especially of elastin.
fecal protease
originate from the pancreas and include trypsin, chymotrypsin and carboxypeptidases. Proteolytic activity of the feces may be evaluated by tests that measure digestion of gelatin or casein-based substrates.
α1-protease inhibitor
α1-antitrypsin.
References in periodicals archive ?
We considered that mutations at the S1/S2 site could alter proteolytic cleavage and modify S fusogenic properties, leading to tropism expansion, systemic spread and, ultimately, FIP.
sKlotho can be generated through 2 different pathways, by an alternative Klotho messenger RNA splicing putatively encoding only KL1 (5) and by a proteolytic cleavage by membrane-anchored A desintegrin and metalloproteinases-17 (ADAM-17) and ADAM-10, which release the full-length extracellular domain into the extracellular space (Fig.
In the existing IFCC reference measurement procedure the 2 measurands, namely the glycated and nonglycated hexapeptides, are derived from the [beta]-chains of hemoglobin by proteolytic cleavage.
7,291,710 "Detection of spectrin and spectrin proteolytic cleavage products in assessing nerve cell damage", licensed exclusively by Banyan Biomarkers from the University of Florida.
We used the N-MID Osteocalcin assay that is specific for intact OC (amino acids 1-49) and the main N-terminal fragment (amino acids 1-43) resulting from proteolytic cleavage after blood collection.
The neurotoxic peptide, amyloid-beta, that is the core constituent of the plaques found in the AD brain, is generated by the proteolytic cleavage of APP by a group of enzymes whose inhibition is a strategy for AD treatment.
Following proteolytic cleavage of proBNP, a 108-amino acid precursor, an N-terminal fragment (NT-proBNP) and BNP are released (2).
Most recently, he co-authored a paper detailing his work on the discovery of a proteolytic cleavage product of ACRP 30, that functions as a Fatty Acid Muscle Oxidation Inducer that causes weight loss in mice without affecting food intake.
Peaks designated category D appeared de novo in serum as a result of proteolytic cleavage of RP peptides by endogenous proteases.
While bound to an IGFBP, the IGFs cannot stimulate the IGF receptor; however, proteolytic cleavage at a single site in the central domain of the IGFBPs results in the release of bioactive IGF (8).
Protein analysis provides additional information on posttranslational modifications, such as glycosylation, phosphorylation, and proteolytic cleavage, that are not visible at the DNA or RNA level.
Soluble serum ACE originates from endothelial cells by proteolytic cleavage by an unidentified protease of the [Arg.