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proteoglycan

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.02 sec.
proteoglycan /pro·teo·gly·can/ (pro″te-o-gli´kan) any of a group of polysaccharide-protein conjugates present in connective tissue and cartilage, consisting of a polypeptide backbone to which many glycosaminoglycan chains are covalently linked; they form the ground substance in the extracellular matrix of connective tissue and also have lubricant and support functions.
pro·te·o·gly·can (prt--glkn, -kn)
n.
Any of various mucopolysaccharides that are bound to protein chains in covalent complexes and occur in the extracellular matrix of connective tissue.

proteoglycan [pro″te-o-gli´kan]
any of a group of glycoproteins found primarily in connective tissue and formed of subunits of glycosaminoglycans (long polysaccharide chains containing amino sugars) linked to a protein core like bristles on a bottle brush. Hydrated proteoglycans form the highly viscous fluid of mucus and the matrix of the intercellular ground substance of connective tissue. Called also mucopolysaccharide.

proteoglycan
any of a group of glycoproteins found primarily in connective tissue and formed of subunits of glycosaminoglycans (long polysaccharide chains containing amino sugars) linked to a protein core like bristles on a bottle brush. Hydrated proteoglycans form the highly viscous fluid of mucus and the matrix of the intercellular ground substance of connective tissue. Called also mucopolysaccharide.


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They have organized the contributions into sections concentrating on glycoprotein and proteoglycan analysis; glycosylation site determination methods; the use of bioinformatic tools for analysis of mass spectrometric data on glycans; analysis of the specific single O-GlcNAc molecule found on nuclear and cytoplasmic proteins; and methods for measuring glycan biomolecular interactions using glycan arrays, mass spectrometry, nuclear magnetic resonance, antibodies, and small molecule inhibitors.
Laboratoires Serobiologiques (LS) has designed Dermican with a unique anti-aging action that targets the metabolism of a specific proteoglycan (lumican) to enhance skin firmness.
This increases the amount of inflammation and the process becomes self-perpetuating, leading to the condition known as degenerative joint disease (DJD) because the body is unable to produce enough glucosamine to generate the proteoglycan needed for repair.
 
 
 
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