Poplawska's research will focus on the inhibitory activity of AAT genetic variants towards three related neutrophil serine proteinases: human neutrophil elastase (HNE), proteinase 3
(PR3) and cathepsin G (CG).
The immunizing peptide was derived from proteinase 3
, a protein that is overexpressed on the surface of leukemia cells in patients with acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), and myelodysplastic syndrome (MDS).
Earlier research suggested that the piece, called PRI, stimulates production of immune system T cells that specifically target proteinase 3
Proteo Biotech AG Compound: Elafin, a human protein that inhibits leukocyte elastase and proteinase 3
Elafin's ability to block the enzymes elastase and proteinase 3
, both of which are involved in tissue damage during inflammatory reactions, makes this protein a promising agent for the treatment of inflammatory lung disorders or severe reperfusion injury occurring after heart attacks, woundings or organ transplantations.
Proteo's Elafin is of human origin and is one of the most potent inhibitors of human elastase and proteinase 3
, and therefore a compound with high biological activity and with less unforeseeable side effects and insignificant allergenic potential compared to most synthetic alternatives.