Protein-tyrosine kinases | definition of protein-tyrosine kinases by Medical dictionary
Also found in: Dictionary
protein-tyrosine kinases A large class of enzymes that catalyse the transfer of phosphate from ATP to tyrosine residues in polypeptides. Their products regulate cell proliferation, survival, differentiation, function and motility. These enzymes are regarded as excellent targets for cancer chemotherapy. Drugs such as imatinib mesylate inhibit these enzymes.
References in periodicals archive
Characterization and phylogenetic analysis of a cDNA encoding the Fes/FER related, non-receptor protein-tyrosine kinase
in the marine sponge Sycon raphanus.
The gene involved in X-linked agammaglobulinemia is a member of the src family of protein-tyrosine kinases
is a pioneer in the study of protein-tyrosine kinases