tyrosine kinase

(redirected from Protein-tyrosine kinase)
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ty·ro·sine ki·nase

an enzyme that phosphorylates tyrosyl residues on certain proteins; many are products of viral oncogenes; a number of receptors (for example, receptors for epidermal growth factor, insulin, etc.) have this enzymatic activity; a misnomer, in that the physiologic substrate is not tyrosine but tyrosyl residues in a protein.

tyrosine kinase

n.
Any of a family of enzymes that phosphorylate tyrosine in certain proteins and play an important role in cell signaling. Mutations that affect their activity or expression can cause leukemia and other cancers.

tyrosine kinase

An enzyme intimately linked to signal transduction–ST, either as a receptor-type TK, which participates in transmembrane signaling, or as an intracellular TK, participating in ST to the nucleus; ↑ or ↓ TK activity is associated with various diseases, and alteration of TK activity at various points in its signaling pathway is of potential therapeutic interest; ↑ TK activity implicated in many CAs and other malignant and nonmalignant diseases, ASHD, psoriasis, inflammation; ↓ TK activity is linked to DM, X-linked agammaglobulinemia

tyrosine kinase

Any of a group of enzymes that influence signaling between cells, esp. as relates to cell growth and death, cellular adhesion and movement, and cellular differentiation. Abnormalities in tyrosine kinases are found in some human diseases, including chronic myeloid (myelogenous) leukemia.
See also: kinase
References in periodicals archive ?
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.
Southern blot analysis of DNA from pedigrees with XLA cases showed restriction fragment length alterations that segregated in an X-linked recessive pattern; detailed analysis disclosed either genomic DNA deletions in the region encompassing Btk or missense point mutations resulting in nonconservative amino acid substitutions at important residues in the putative protein-tyrosine kinase domain (89).
Receptor protein-tyrosine kinases and their signal transduction pathways.

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