protein tyrosine phosphatases

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protein tyrosine phosphatases

A family of phosphate hydrolyzing enzymes that help regulate signaling between cells. Some diseases linked to abnormalities in protein tyrosine phosphatases include allergies, asthma, diabetes mellitus, obesity, and Alzheimer's disease.
References in periodicals archive ?
Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.
Preferential oxidation of the second phosphatase domain of receptor-like PTP-a revealed by an antibody against oxidized protein tyrosine phosphatases," Proceedings of the National Academy of Sciences of the United States ofAmerica, vol.
Protein tyrosine phosphatases play an integral role within the insulin signaling cascade by negatively regulating signal transduction.
Single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance.
Data from a population-based tissue bank covering the northern half of Sweden indicated that both the protein tyrosine phosphatase N22 (PTPN22) 1858T variant and antibodies against cyclic citrullinated peptide (anti-CCP) are independently associated with future onset of rheumatoid arthritis (RA).
Laforin is a cell membrane and endoplasmic reticulum associated protein tyrosine phosphatase.
Ileana Cuevas from the Daniel Sanchez Laboratory (University of General San Martin, San Martin, Argentina) reported the presence of a farnesylated protein tyrosine phosphatase in T.
This acquisition strengthens Kinetek's drug programs by adding proprietary assets and expertise for the development of protein tyrosine phosphatase inhibitors, an undeveloped therapeutic market with significant potential for treating cancer and other diseases.
AKB-9778 is a first-in-class human protein tyrosine phosphatase beta (HPTP) inhibitor that works to activate Tie2, a receptor on vascular endothelial cells which promotes vascular stability, preventing abnormal blood vessel growth and vascular leak.
This proposal focuses on the role of SHP2 and other protein tyrosine phosphatase (PTP) in BC metastasis and comprises three parallel approaches.
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori.

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