phosphatase

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phosphatase

 [fos´fah-tās]
any of a group of enzymes capable of catalyzing the hydrolysis of esterified phosphoric acid, with liberation of inorganic phosphate, found in practically all tissues, body fluids, and cells, including erythrocytes and leukocytes.
acid phosphatase see acid phosphatase.
alkaline phosphatase see alkaline phosphatase.

phos·pha·tase

(fos'fă-tās),
Any of a group of enzymes (EC 3.1.3.x) that liberate orthophosphate from phosphoric esters.
See also: phosphohydrolases.

phosphatase

/phos·pha·tase/ (-tās) any of a group of enzymes that catalyze the hydrolytic cleavage of inorganic phosphate from esters.

phosphatase

(fŏs′fə-tās′, -tāz′)
n.
Any of numerous enzymes that catalyze the removal of phosphate groups by hydrolysis of phosphate ester bonds. They act in the opposite manner to kinases and are important in metabolism and cell signaling.

phosphatase

[fos′fətāz]
an enzyme that acts as a catalyst in chemical reactions involving phosphorus. It is present in serum, semen, the kidney, and the prostate. It is essential in the calcification of bone. See also catalyst, enzyme.

phos·pha·tase

(fos'fă-tās)
Any of a group of enzymes (EC sub-subclass 3.1.3) that liberate inorganic phosphate from phosphoric esters.

phosphatase

An enzyme that removes phosphate groups from a molecule.

phosphatase

an enzyme that catalyses the release of phosphate from a molecule. For example, in the mammalian liver phosphorylated glucose can be broken down to glucose with a phosphatase enzyme. see GLYCOGEN.

phos·pha·tase

(fos'fă-tās)
Any of a group of enzymes (EC sub-subclass 3.1.3) that liberate inorganic phosphate from phosphoric esters.

phosphatase(s) (fos´fətās),

n a group of enzymes that are distributed throughout most cells and body fluids and are characterized by their ability to hydrolyze a wide variety of monophosphate esters to alcohols and inorganic phosphate.
phosphatase, acid,
n a group of phosphatases (e.g., serum, liver, prostate) with optimal activity below a pH level of 7. Elevated serum levels have been observed in metastatic breast and prostatic cancer; Paget's, Gaucher's, and Niemann-Pick diseases and in myelocytic leukemia.
phosphatase, alkaline,
n a group of phosphatases (e.g., serum, liver, bone) whose optimal activity ranges near a pH level of 9.8. Elevated blood levels occur in Paget's disease and pregnancy, whereas low levels are characteristic of dwarfism and a generalized nutritional protein deficiency.

phosphatase

any of a group of enzymes capable of catalyzing the hydrolysis of esterified phosphoric acid, with liberation of inorganic phosphate, found in practically all tissues, body fluids and cells, including erythrocytes and leukocytes.

acid phosphatase
a lysosomal enzyme that hydrolyzes phosphate esters liberating phosphate, showing optimal activity at a pH between 3 and 6; found in erythrocytes, prostatic tissue, spleen, kidney and other tissues.
alkaline phosphatase
an isoenzyme showing optimal activity at a pH of about 10; found in bone, liver, kidney, leukocytes, adrenal cortex and other tissues, often used in clinical diagnosis of liver and/or bone damage. Called also AP; see also alkaline phosphatase.
phosphatase inhibitor-1
inhibitor of phosphatase enzymes known to activate glycogen synthesis or inactivate glycogen breakdown. Need to themselves be phosphorylated by cAMP-dependent kinases before they are effective in their inhibitory activity.
References in periodicals archive ?
Hepatocytes deformation induced by cyanobacteria toxins reflects inhibition of protein phosphatases.
Blockade of protein phosphatase 2B activity in the amygdala increases anxiety- and depression-like behaviors in mice.
Integrin [alpha]2[beta]1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3[beta].
PP2C is involved in various cellular events and signaling pathways via the dephosphorylation of various substrates, and is a unique protein phosphatase, being an [Mg.
Conversely, protein phosphatase 1 (PP1) and glucocorticoids are neurophysiological phenomena that limit what can be learned and cause forgetfulness.
David Warburton, MD, director of Developmental Biology and Regenerative Medicine at The Saban Research Institute, and El-Hashash provided the first evidence that the enzyme Eya1 protein phosphatase controls tight junction and permeability barrier formation in the lung epithelium.
Kovach, "Lixte has emphasized the potential importance of its protein phosphatase inhibitors to the treatment of a variety of cancer types.
Because recombinant HDAC6 binds directly to the protein phosphatase 1 (PP1) catalytic subunit, TSA disrupts endogenous HDAC6-PP1 complexes and activates PP1 (Brush et al.
SYNTHESIS AND TESTING OF A 5-SUBSTITUTED NORCANTHARIDIN ANALOG AS A PROTEIN PHOSPHATASE 5 INHIBITOR.
University of Newcastle researchers* identified Midline-1 (also known as TRIM 18) as a novel target that regulates airway inflammation and promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity.
We have identified a small molecule, guanabenz, which binds to a regulatory subunit of protein phosphatase 1, PPP1R15A/GADD34, selectively disrupting the stress-induced dephosphorylation of the alpha subunit of translation initiation factor 2 (eIF2 alpha).
Extracellular calcium may activate protein phosphatases (e.

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