protein kinase

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Related to Protein kinase c-alpha: Protein kinase B

protein kinase

/pro·tein ki·nase/ (pro´tēn ki´nās) an enzyme that catalyzes the phosphorylation of serine, threonine, or tyrosine groups in enzymes or other proteins, using ATP as a phosphate donor.

protein kinase

n.
Any of a group of kinases that phosphorylate the amino acids serine, threonine, and tyrosine in certain proteins, that regulate essential aspects of cell growth and movement, and that can cause cancer and other diseases when dysfunctional.

protein kinase (PKA)

a protein that catalyzes the transfer of a phosphate group from adenosine triphosphate to produce a phosphoprotein.

protein kinase

This name was officially retired in 2005; however, although the term is nonspecific, it is still in common use. It is now formally divided into:
• EC 2.7.11.1, non-specific serine/threonine protein kinase;
• EC 2.7.11.8, Fas-activated serine/threonine kinase;
• EC 2.7.11.9, Goodpasture antigen-binding protein kinase;
• EC 2.7.11.10, IκB kinase;
• EC 2.7.11.11, cAMP-dependent protein kinase;
• EC 2.7.11.12, cGMP-dependent protein kinase;
• EC 2.7.1.13, protein kinase C;
• EC 2.7.11.21, polo kinase;
• EC 2.7.11.22, cyclin-dependent kinase;
• EC 2.7.11.24, mitogen-activated protein kinase;
• EC 2.7.11.25, mitogen-activated protein kinase kinase kinase;
• EC 2.7.11.30, receptor protein serine/threonine kinase; and
• EC 2.7.12.1, dual-specificity kinase.

protein kinase

an ENZYME that catalyses the transfer of a phosphate group from ATP to an AMINO ACID in a PROTEIN. In this way, the activity of enzymes can be decreased or increased. By thus altering proteins, kinases are thought to be important in mediating various processes in the CELL.
References in periodicals archive ?
ISIS 3521 is a promising new antisense anticancer compound that is a potent, selective inhibitor of protein kinase C-alpha (PKC-alpha) expression.
Abstract #809 - Coagulation and Complement Effects of an Antisense Phosphorothioate Oligonucleotide Targeting Protein Kinase C-alpha.
The poster entitled "A Phase I trial of ISIS 3521, an antisense inhibitor of protein kinase C-alpha, combined with carboplatin and paclitaxel" was presented by Alan Yuen, M.
In the study, antisense compounds were shown to selectively inhibit the protein kinase C-alpha (PKC-alpha) gene in vivo following systemic administration.

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