isoform

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isoform

One of two or more proteins coded independently by different genes, which have identical or nearly identical structures and functions.
References in periodicals archive ?
In the search to understand these molecular processes, researchers uncovered an important new DAF-16 isoform - DAF-16d/f - that collaborates with other DAF-16 protein isoforms to regulate longevity.
Recent scientific research is revealing strong correlations between the presence and ratio of protein isoforms versus cancer diagnosis, staging and therapeutic response, with important quality of life implications to the patient and major potential cost savings for the health care system," said Jeffrey N.
However, with up to 30,000 or more protein variants in a single cell, protein isoform differentiation and measurement has been a major challenge in the development of clinical diagnostic assays," said Jeffrey N.
The companies believe that the ability to rapidly extract and recover diagnostically and commercially useable protein isoforms from cell membranes is unique to PCT and the TDI reagents, and that this capability positions the companies with game-changing abilities to exploit this critical class of membrane proteins as diagnostic biomarkers.
Despite the fact that alternative splicing substantially increases the diversity of this locus, most of these putative protein isoforms have not been isolated, with the exception of a few proteins encoded by KLK2 and KLK3 variants (22).
Inhibition of interactions and interconversions of prion protein isoforms by peptide fragments from the C-terminal folded domain.
The company also conducts functional in vitro testing of the protein isoforms for determining pharmacological differences among the variants.
The protein isoform expressed in embryonic cardiac and skeletal muscle cells is unique to this developmental stage [5].
MS has been proposed as a good alternative platform for the development of a quantitative assay for tau because it can best measure tryptic peptides that are conserved across protein isoforms and are infrequently modified (total tau) with high specificity.
MenaCalc is a diagnostic test that predicts metastasis based on the amount of Mena protein isoforms that exist in a cancerous tumor sample.
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver.
A single VEGF gene gives rise to three protein isoforms (VEGF120, VEGF164, and VEGF188) through alternative mRNA splicing in mice (Shima et al.

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