protein folding

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Related to Protein folding in vivo: Protein folding in vitro

protein folding

The shaping of a protein into its unique three-dimensional conformation from the linked amino acids of which it is composed.

protein folding

The process by which proteins acquire their normal, energetically-favourable, three-dimensional form. The folding has long been believed to be specified by the amino acid sequence, but recent research suggests that proteins may fold into abnormal shapes by mechanisms not yet determined. Abnormal folding results in loss of normal protein function but also in proteolytic degradation and the accumulation of fragments that form insoluble plaques in the various organs including the brain and the liver. This is believed to be the way in which the characteristic plaques and fibrillary tangles of ALZHEIMER'S DISEASE occur.