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protein C deficiency

   Also found in: Wikipedia 0.01 sec.
protein C deficiency
A condition characterized by a deficiency of vitamin K dependent plasma protein C and protein S, both natural anticoagulants; PCD is either AD of variable penetration, or acquired, and due to DIC, warfarin therapy, hepatic disease and postoperatively


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Reported causes of thrombophilia in HIV-infected subjects include antiphospholipid syndrome [1], increased platelet activation [1], elevated homocysteinemia [2], elevated plasma factor VII activity [2], lupus anticoagulant [3], activated protein C resistance [3], protein C deficiency [3,4], and acquired protein S deficiency [4-10].
These protein deficiencies/abnormalities are genetic and include entities such as antithrombin deficiency, protein C deficiency, protein S deficiency, Factor V Leiden mutation, prothrombin 20210, and dysfibrinogenemia, among others.
 
 
 
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