protease

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endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

pro·te·ase

(prō'tē-āz),
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (break) polypeptide chains.

protease

/pro·te·ase/ (pro´te-ās) endopeptidase.

protease

(prō′tē-ās′, -āz′)
n.
Any of various enzymes, including the endopeptidases and exopeptidases, that catalyze the hydrolytic breakdown of proteins. Also called peptidase.

protease

[prō′tē·ās]
an enzyme that is a catalyst in the breakdown of peptide bonds that join the amino acids in a protein. See also proteolysis.

pro·te·ase

(prō'tē-ās)
Descriptive term for proteolytic enzymes, both endopeptidases and exopeptidases; enzymes that hydrolyze (i.e., break) polypeptide chains.

protease

One of a range of protein-splitting enzymes. One focus of current interest in proteases is in their role in breaking down tissue barriers in the spread of cancer. High concentrations of the activator of one of these proteases has been found to be associated with a poor outlook in cancers of the colon and rectum.

protease

any enzyme that splits proteins, such as PEPSIN, TRYPSIN, EREPSIN or RENNIN.

protease

; proteinase enzyme that breaks down/proteolyses protein

protease

any proteolytic enzyme.

protease-antiprotease imbalance
thought to play a part in the pathogenesis of emphysema by permitting excessive proteolysis, especially of elastin.
fecal protease
originate from the pancreas and include trypsin, chymotrypsin and carboxypeptidases. Proteolytic activity of the feces may be evaluated by tests that measure digestion of gelatin or casein-based substrates.
α1-protease inhibitor
α1-antitrypsin.
References in periodicals archive ?
In vitro assays have shown that DP100 does not degrade phytase, in fact, the protease benefit is maintained even when superdosing phytase.
Mukesh and colleagues were studied in 2012, on the proteases produced by Bacillus sp.
This is where NSP4 differs from the other three known neutrophil serine proteases, which are similar in molecular structure, but have a different recognition motif.
Molecular weight of the proteases was estimated by comparing the relative mobility of proteins of different molecular size using a standard molecular marker 3 to 43kDa (Bio-rad-USA).
Microbial proteases are obtained through fermentative processes (POZA et al.
London, Nov 29 (ANI): A new study has demonstrated that irreversible covalent inhibition can increase selectivity, potency and duration of action, broadens applications for targeted covalent drugs to the protease gene family.
Flatworms taken from mice treated with the drug showed reduced activity of the cysteine protease called cathepsin B, suggesting that this enzyme is a prime target of K11777.
The HIV protease inhibitor project is targeted at inhibition of the HIV protease enzyme and is in the pre-clinical research phase.
The license covers a fundamental protease selection technology to create and select for proteases with entirely new specificities and activities, as well as the ability to optimize the pharmaceutical characteristics of existing protease drug leads.
An increase in basic residues near the cleavage site, either as a result of nucleotide insertion or substitution, allows the HA0 precursor to be cleaved by ubiquitous host proteases (5).
When protease inhibitors began selling in December, ADAPs faced a triple threat: How to afford at least one and give it to only the patients as they could guarantee a constant supply - even as patients who had shunned treatment until the proteases made headlines this spring suddenly started lining at their doors.
As wound therapies become more advanced and the role of proteases in stalled, complex wounds is better understood, clinicians are increasingly realising that "you can't treat what you can't see".

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