protamine

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protamine

 [pro´tah-min]
any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol. Protamines neutralize heparin, and protamine sulfate is used as an antidote in heparin overdosage, administered intravenously.

pro·ta·mine

(prō'tă-mēn, -min),
Any of a class of proteins, highly basic because rich in l-arginine and simpler in constitution than the albumins and globulins, etc., found in fish spermatozoa in combination with nucleic acid; the protamines have a histonelike function and are present in mammalian sperm; neutralizes anticoagulant action of heparin; used in the preparation of several long-acting insulin preparations.

protamine

/pro·ta·mine/ (prōt´ah-min) one of a class of basic proteins occurring in the sperm of certain fish, having the property of neutralizing heparin; the sulfate salt is used as an antidote to heparin overdosage.

protamine

(prō′tə-mēn′, -mĭn) also

protamin

(-mĭn)
n.
Any of a group of arginine-rich proteins that bind to and package DNA in the sperm nucleus. Protamines are used in long-acting formulations of insulin and to neutralize the anticoagulant effects of heparin.

pro·ta·mine

(prō'tă-mēn)
Any of a class of proteins found in fish sperms in combination with nucleic acid; neutralizes anticoagulant action of heparin.

protamine

any of a class of simple proteins, soluble in water, not coagulated by heat, and precipitated from aqueous solution by addition of alcohol, found combined with nucleic acids in the sperm of certain fish, and having the property of neutralizing heparin. Protamine sulfate is used as an antidote to heparin overdosage.

protamine paracoagulation
used to examine a blood sample for fibrin monomers and fibrinogen-split products.
protamine zinc insulin (PZI)
see insulin.
References in periodicals archive ?
Altered protamine expression and diminished spermatogenesis: what is the link'?
Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fert i I izing capacity, andmay reflect other abnormalities of spermi-ogenesis.
Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability.
Further sensitivity to subtle changes in DNA is gained by incubation of the cells in the presence of Proteinase K, which removes protamines that otherwise impede DNA migration through the agarose.
During chromatin packing 85 per cent of the histones are replaced by protamine while the residual histones act as marker of genes which are expressed in early embryonic development.
DNA and total protamine masses in individual sperm from fertile mammalian subjects.