Prostatic intraepithelial neoplasia (PIN) is broadly characterized by the growth of cytologically atypical cells within architecturally benign prostatic ducts
or acini and is classified as either low or high grade (LGPIN or HGPIN).
Periurethral prostatic ducts
are particularly susceptible to estrogen-driven cancers (Bosland et al.
41] ZhouZ, Flesken-Nikitin A, Nikitin AY Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts
3) Ductal tumors mainly arise from primary periurethral prostatic ducts
whereas acinar tumors arise from other periurethral prostatic ducts
Small cell carcinoma of the prostate is believed to originate from epithelial cells of prostatic ducts
and acini, as well as the endothelium of the prostatic urethra.
Non-specific granulomatous prostatitis and xanthogranulomatous prostatitis are likely caused by a blockage of prostatic ducts
and stasis of gland secretions.
Prostatitis, a lower urinary tract infection, occurs by retrograde entry of organisms into the prostatic ducts
via urethra from oral, anal, genital intercourse or masturbating practices, by hematogenous spread from other foci, or lymphatic extension from infected kidneys.
Spread of adenocarcinoma within prostatic ducts
and acini: morphologic and clinical correlations.
10] Typically, entry of microorganisms occurs via the urethra into the prostatic ducts
due to direct migration or with intraprostatic reflux of urine.
3) Additionally, invasive prostatic acinar adenocarcinoma, prostatic ductal adenocarcinoma, and urothelial carcinoma involving prostatic ducts
mimic IDC-P morphologically.
3] Originally, ductal carcinoma of the prostate was thought to have arisen from the prostatic utricle in the form of a mullerian ductal structure; however, immunohistochemistry studies have since shown that this rare form of prostate cancer arises from the prostatic ducts
The two main techniques are (1) removal of the prostatic adenoma using the technique of a Millen simple retropubic prostatectomy, excising the adenoma tissue containing the prostatic ducts
and most acini, leaving the surgical capsule and seminal vesicles intact,[sup.