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A peroxide (-O-O-) group that bridges two atoms that are both parts of a larger molecule.
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Structure of prostaglandin H2 synthase-1 (COX-1) and its NSAID binding sites.
Led by Michael Garavito, associate professor of biochemistry and molecular biology, they determined the molecular structure of the enzyme, prostaglandin H2 synthase, or PGHS.
Scientists have known since the 1960s that aspirin and other nonsteroidal anti-inflammatory drugs relieve pain and lessen swelling by disrupting two enzymes, PGHS-1 and PGHS-2, versions of the compound prostaglandin H2 synthase.

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