Proscar


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Related to Proscar: Avodart

finasteride

Propecia, Proscar

Pharmacologic class: Androgen inhibitor

Therapeutic class: Sex hormone, hair regrowth stimulant

Pregnancy risk category X

Action

Suppresses dihydrotestosterone levels by inhibiting the hepatic enzyme 5-alpha reductase, which converts testosterone to dihydrotestosterone in prostate, liver, and skin

Availability

Tablets: 1 mg (Propecia), 5 mg (Proscar)

Indications and dosages

Symptomatic benign prostatic hypertrophy (BPH)

Adults: 5 mg P.O. daily

To reduce risk of progression of BPH symptoms

Adults: 5 mg P.O. daily (Proscar) given with doxazosin

Male-pattern baldness

Adults: 1 mg P.O. daily

Off-label uses

• Acne in women
• Hirsutism

Contraindications

• Hypersensitivity to drug or its components
• Pregnant patients, women who may potentially be pregnant

Precautions

Use cautiously in:
• hepatic impairment, obstructive uropathy, increased risk of high-grade prostate cancer, decrease in serum prostate-specific antigen (PSA) level
• women (not indicated)
• children (not indicated).

Administration

• Give with or without food.
• Know that female patients who are or may be pregnant shouldn't handle crushed or broken tablets. (Tablets are coated, so handling of intact tablets doesn't pose a problem.)

Adverse reactions

CNS: dizziness, headache, asthenia

EENT: lip swelling

GU: erectile dysfunction, decreased ejaculate volume, decreased libido, testicular pain, gynecomastia

Musculoskeletal: back pain

Skin: rash

Interactions

Drug-drug.Theophylline: increased theophylline clearance

Drug-diagnostic tests.PSA: 50% decrease

Patient monitoring

• Carefully evaluate sustained PSA increases during therapy.
• Monitor fluid intake and output closely.

Patient teaching

• Tell patient he may take drug with or without food.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Inform patient that he may experience erectile dysfunction and decreased ejaculate. Advise him to discuss these issues with prescriber.
• Caution female caregiver or companion who is or may be pregnant not to handle crushed or broken tablets.
• Tell patient he may need at least 6 months of therapy for BPH treatment and at least 3 months to see improvement in male-pattern baldness.
• Inform patient with BPH that he'll undergo periodic digital rectal exams.
• Instruct patient not to donate blood for at least 1 month after last dose.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Proscar

(prŏs′kär′)
A trademark for the drug finasteride.

Proscar®

Finasteride, see there.

Proscar

A brand name for FINASTERIDE.
References in periodicals archive ?
Both Propecia and Proscar are manufactured by Merck.
Finasteride is now marketed as both Proscar and Propecia, one for each indication.
I take Proscar for an enlarged prostate and a water tablet called Burinex.
I was prescribed proscar finastride eight months ago, but I do not feel it has made any difference.
Propecia is the same medication as Proscar, which is used for benign prostatic hypertrophy at the five-milligram strength.
Its active ingredient, finasteride, is used in larger doses under the name Proscar to treat enlarged prostate glands in men.
We expect Proscar to be available in many major world markets later this year.
One, Proscar, which is used to treat enlarged prostate disease, has been filed with the FDA.
In Merck's case, analysts are particularly optimistic about the prospects for Proscar, a drug to treat an enlarged prostate, a condition affecting elderly men-a growing population group in the United States and other industrialised countries.
Another independent analysis of the prostate-gland shrinking effects of Proscar was conducted and published in the Journal of the American Statistical Association.
The FDA has approved eight other drugs to treat symptoms of BPH: Proscar, (finasteride), Avodart (dutasteride), Jalyn (dutasteride plus tamsulosin), and the alpha blockers: Hytrin (terazosin), Cardura (doxazosin), Flomax (tamsulosin), Uroxatral (alfuzosin) and Rapaflo (silodosin).
Washington, Mar 19 (ANI): Men who take the drug finasteride, commonly marketed under the trademark names Propecia and Proscar, may report an on-going reduction in sex drive, and in some cases, prolonged periods of erectile dysfunction even after they stop using the medications, according to a new study by The George Washington University School of Medicine and Health Sciences.