Propecia


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Related to Propecia: Rogaine, minoxidil

finasteride

Propecia, Proscar

Pharmacologic class: Androgen inhibitor

Therapeutic class: Sex hormone, hair regrowth stimulant

Pregnancy risk category X

Action

Suppresses dihydrotestosterone levels by inhibiting the hepatic enzyme 5-alpha reductase, which converts testosterone to dihydrotestosterone in prostate, liver, and skin

Availability

Tablets: 1 mg (Propecia), 5 mg (Proscar)

Indications and dosages

Symptomatic benign prostatic hypertrophy (BPH)

Adults: 5 mg P.O. daily

To reduce risk of progression of BPH symptoms

Adults: 5 mg P.O. daily (Proscar) given with doxazosin

Male-pattern baldness

Adults: 1 mg P.O. daily

Off-label uses

• Acne in women
• Hirsutism

Contraindications

• Hypersensitivity to drug or its components
• Pregnant patients, women who may potentially be pregnant

Precautions

Use cautiously in:
• hepatic impairment, obstructive uropathy, increased risk of high-grade prostate cancer, decrease in serum prostate-specific antigen (PSA) level
• women (not indicated)
• children (not indicated).

Administration

• Give with or without food.
• Know that female patients who are or may be pregnant shouldn't handle crushed or broken tablets. (Tablets are coated, so handling of intact tablets doesn't pose a problem.)

Adverse reactions

CNS: dizziness, headache, asthenia

EENT: lip swelling

GU: erectile dysfunction, decreased ejaculate volume, decreased libido, testicular pain, gynecomastia

Musculoskeletal: back pain

Skin: rash

Interactions

Drug-drug.Theophylline: increased theophylline clearance

Drug-diagnostic tests.PSA: 50% decrease

Patient monitoring

• Carefully evaluate sustained PSA increases during therapy.
• Monitor fluid intake and output closely.

Patient teaching

• Tell patient he may take drug with or without food.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Inform patient that he may experience erectile dysfunction and decreased ejaculate. Advise him to discuss these issues with prescriber.
• Caution female caregiver or companion who is or may be pregnant not to handle crushed or broken tablets.
• Tell patient he may need at least 6 months of therapy for BPH treatment and at least 3 months to see improvement in male-pattern baldness.
• Inform patient with BPH that he'll undergo periodic digital rectal exams.
• Instruct patient not to donate blood for at least 1 month after last dose.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Propecia

(prə-pē′shə)
A trademark for the drug finasteride.

Propecia®

Finasteride Esthetic medicine An agent for treating male pattern hair loss–androgenetic alopecia on the vertex and the anterior midscalp area Contraindications ♀, children. See Male-pattern baldness.

Propecia

A brand name for FINASTERIDE.

Patient discussion about Propecia

Q. i wan't to know. what are the side effects of propecia pills. and more about them please

A. my dad took it.. it helped a bit- but not too much. as i recall the side effects his prescribing Dr. was worried about were allergic reactions (skin rash, problem breathing, edema). but he said it can cause impotence and even breast cancer at men! he told him to check his breast for lumps every now and then.

Q. Do you know if Propecia can truly stop hair loss and even grow back hair. do you have any statistics about it? do you know if there are any side effects to this medication?

A. it does work but there is some side affects, as in E.D. while you are on the med.

More discussions about Propecia
References in periodicals archive ?
A spokesman for Merck, the drug's maker, said, "No causal relationship has been established between Propecia and persistent sexual side effects.
He recently published a study in the Journal of Sexual Medicine, which found the ingredient finasteride, which is found in Propecia, could cause persistent sexual dysfunction, including low sexual desire, erectile dysfunction and problems with orgasms.
Propecia (finasteride) is a drug that was originally developed to treat prostate problems by blocking the action of an enzyme that acts on testosterone hormone both in the prostate gland and in scalp hair follicles.
In ongoing studies of more than 1,800 men with mild to moderate baldness, those taking Propecia reported more positive self-assessments of hair growth on the back of their head, the top of the head and on the midscalp area after two years, compared with men taking a placebo pill.
Firstly, even if clinical trials continue as planned it is unlikely that Propecia will be available in this country much before the year 2000.
Mag-Gro is an all-natural process without the side effects that might accompany topical chemical treatments or ingested hormones, such as Minoxidil and Propecia.
Some studies have found that nine in ten men taking Propecia stop balding, and around 65 per cent experience regrowth.
Some of the biggest changes in search popularity since last year were seen with Levitra, which moved to 8th position from 26th, Propecia (Merck) a hair- growth drug, which moved up to 7th position from 16th, and Lexapro (Forrest), which moved from 15th to 10th to became the most searched for anti-depressant, replacing Zoloft (Pfizer) which was ranked 6th last year and is now 13th.
Q I WAS reading your column recently regarding the drug Propecia.
THE first anti-baldness pill, Propecia, will soon be available, but you won't get it prescribed on the NHS.
There are, however, some drawbacks: The pill, which will be marketed as a prescription medicine under the brand name Propecia, can cause birth defects and so is not approved for women.