promoter

(redirected from Promoter site)
Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.

pro·mo·ter

(prō-mō'tĕr),
1. In chemistry, a substance that increases the activity of a catalyst.
2. In molecular biology, a DNA sequence at which RNA polymerase binds and initiates transcription.

promoter

/pro·mo·ter/ (pro-mo´ter)
1. a segment of DNA usually occurring upstream from a gene coding region and acting as a controlling element in the expression of that gene.
2. a substance in a catalyst that increases its rate of activity.
3. a type of epigenetic carcinogen that promotes neoplastic growth only after initiation by another substance.

promoter

(prə-mō′tər)
n.
1. One that promotes, especially an active supporter or advocate.
2. A financial and publicity organizer, as of a boxing match or an artistic performance.
3. Genetics The region of an operon that acts as the initial binding site for RNA polymerase.

promoter

[-mō′tər]
Etymology: L, promovere, to move forward
1 a DNA sequence that initiates transcription of the genetic code.
2 a cocarcinogen that encourages cells altered by initiators to reproduce more rapidly than normal, increasing the probability of malignant transformation. Examples include chlorophenothane (DDT), phenobarbital, saccharin, sunlight, and some chemicals in cigarette smoke. The effects of promoters are sometimes reversible.

pro·mo·ter

(prŏ-mō'tĕr)
1. chemistry A substance that increases the activity of a catalyst.
2. molecular biology A DNA sequence at which RNA polymerase binds and initiates transcription.

promoter

In genetics, a nucleotide sequence at the start of a gene to which RNA polymerase must bind before the process of transcription can start. The promoter is located UPSTREAM of the gene it regulates.

promoter

a cis- acting (see CIS -ACTIVE) NUCLEOTIDE sequence on a DNA molecule which promotes the initiation of TRANSCRIPTION by allowing the assembly of proteins, including RNA POLYMERASE (or its equivalent), in transcriptional complexes. see OPERON MODEL. The promoter generally lies UPSTREAM of the transcription start site.

promoter

a specific DNA sequence to which RNA polymerase binds and signals where RNA synthesis (transcription) should begin.

internal promoter
a class of enhancers which are gene-specific sequences that increase transcription.
promoter region
the non-coding nucleotide sequence at the transcription start region that is characterized by the presence of a number of conserved or consequence sequences.

Patient discussion about promoter

Q. I am interested in social service. So what can I do to promote a healthy pregnancy?

A. Hi friend, once you're pregnant, a regular checkup is the key. Your health professional might want to monitor your baby's growth and watch for problems that can only be detected by checking your blood pressure, urine, and blood regularly. Anything you do that harms your body harms your fetus. Take special care: To avoid: tobacco smoking, alcohol, drugs, chemicals, radiation (as from X-rays), and sources of infection. Keep your body temperature from getting too high [over 100.4° (38°)] by treating any fevers with acetaminophen (such as Tylenol) and avoiding exercise or activity that overheats you. Also avoid high-temperature hot tubs and saunas. Take extra-good care of yourself while you're pregnant. Everything healthy you do for your body benefits your growing fetus. Rest when you need it, eat well, and exercise regularly.

More discussions about promoter
References in periodicals archive ?
In our model, activation of the construct via promoter sites other than the EREs is avoided by using only a minimal TATA box in the construct, resulting in low background activity.
Knowles suggests that over the course of evolution, retrotransposons that had randomly inserted themselves into promoter sites turned on genes that otherwise might have stayed off.
It has been suggested that the -344T/C variant by itself does not directly influence promoter activity rather, binding of steroidogenic factor-1 (SF-1) to this site downregulates activity of CYP11B2 promoter by making SF-1 less available to functionally affect other CYP11B2 promoter sites, which could alter expression of the gene (10).