hematopoietic stem cell

(redirected from Prolymphocytic)
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hematopoietic stem cell

an actively dividing cell that is capable of self-renewal and of differentiation into any blood cell lineage.

hematopoietic stem cell

A progenitor cell in the bone marrow that can replicate itself as well as produce precursor cells of the various blood cell lineages.
See also: cell

Hematopoietic stem cell

A cell that can develop into any type of specialized blood cell.
References in periodicals archive ?
Blinatumomab has also received orphan drug designation from the FDA for the treatment chronic lymphocytic leukemia (CLL), hairy cell leukemia, prolymphocytic leukemia and indolent B-cell lymphoma and from the EMA for the treatment of indolent B-cell lymphoma, CLL and mantle cell leukemia (MCL).
Similar patterns of V[kappa] gene usage but different degrees of somatic mutation in hairy cell leukemia, prolymphocytic leukemia, Waldenstrom's macroglobulinemia, and myeloma.
Prolymphocytic leukemia (PLL) is a rare lymphocytic disorder characterized by marked lymphocytosis and splenomegaly and represents only 2% of all mature lymphocytic leukemias in adults over the age of 30.
Guillain-Barre syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature.
The phenomenon of endogenously produced heparin-like anticoagulants has been previously described, but is typically associated with hematological malignancies, such as multiple myeloma, chronic lymphoid leukemia, T-cell prolymphocytic leukemia and systemic mastocytosis.
Food and Drug Administration for three indications: T-cell non- Hodgkin's lymphoma, including CTCL; CLL and related leukemias including T-cell prolymphocytic leukemia, adult T-cell leukemia, and hairy cell leukemia; and for treatment of B-cell acute lymphoblastic leukemia (ALL).
Of the latter, 12 patients were diagnosed with PTCL-NOS, six with Angioimmunoblastic Lymphadenopathy with Dysproteinemia (AILD), one with enteropathy-associated T-cell lymphoma, one with NK-cell lymphoma, and one with T-cell prolymphocytic leukemia (T-PLL).
These included 25 cases of MCL, 41 cases of CLL/SLL, 3 cases of hairy cell leukemia, 4 of follicular lymphoma, 5 of diffuse large B-cell lymphoma, 2 of Burkitt lymphoma, 1 of prolymphocytic leukemia B-cell type, 1 of lymphoplasmacytic lymphoma, 5 of acute lymphoblastic leukemia, and 10 cases of marginal zone lymphoma.
Up to 10% of the cells may be larger and nucleolated, and if less than 55% of such cells are observed in a peripheral smear, a diagnosis of prolymphocytic transformation of CLL - a combination of CLL and prolymphocytic leukemia (PLL) - should be considered.
We have added clinical guidelines for both hairy cell leukemia and T-cell prolymphocytic leukemia to our NCCN Guidelines for NHL," said Andrew D.
antibody constructs and Amgen has received orphan drug designation from the FDA for the treatment of ALL, chronic lymphocytic leukemia (CLL), hairy cell leukemia, prolymphocytic leukemia and indolent B-cell lymphoma and from the European Medicines Agency for the treatment of indolent B-cell lymphoma, ALL, CLL and mantle cell leukemia (MCL).