Prolyl 4-hydroxylase | definition of Prolyl 4-hydroxylase by Medical dictionary
prolyl hydroxylase (redirected from Prolyl 4-hydroxylase)
Also found in: Acronyms
an enzyme that catalyzes the hydroxylation of certain prolyl residues in collagen precursors using molecular oxygen, ferrous ion, ascorbic acid, and α-ketoglutarate; a vitamin C deficiency directly affects the activity of this enzyme; one form of this enzyme (prolyl 4-hydroxylase) synthesizes 4-hydroxyprolyl residues while another produces 3-hydroxyprolyl residues.
References in periodicals archive
mRNA levels for [alpha]-subunit of prolyl 4-hydroxylase and fibrillar collagens in immobilized rat skeletal muscle.
Structure and Expression of the human gene for the [alpha] subunit of prolyl 4-hydroxylase.
Cell density regulates prolyl 4-hydroxylase activity independent of mRNA levels.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis.