prolyl hydroxylase

(redirected from Prolyl 4-hydroxylase)
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pro·lyl hy·drox·y·lase

an enzyme that catalyzes the hydroxylation of certain prolyl residues in collagen precursors using molecular oxygen, ferrous ion, ascorbic acid, and α-ketoglutarate; a vitamin C deficiency directly affects the activity of this enzyme; one form of this enzyme (prolyl 4-hydroxylase) synthesizes 4-hydroxyprolyl residues while another produces 3-hydroxyprolyl residues.
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References in periodicals archive ?
mRNA levels for [alpha]-subunit of prolyl 4-hydroxylase and fibrillar collagens in immobilized rat skeletal muscle.
Structure and Expression of the human gene for the [alpha] subunit of prolyl 4-hydroxylase.
Cell density regulates prolyl 4-hydroxylase activity independent of mRNA levels.
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.
Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis.