PCSK1

(redirected from Prohormone convertase 1)

PCSK1

A gene on chromosome 5q15-q21 that encodes a peptidase S8 family convertase involved in processing pairs of basic amino acid residues located on prohormones and other protein precursors (e.g., POMC, renin, enkephalin, dynorphin, somatostatin and insulin).

Molecular pathology
Defects in PCSK1 cause proprotein convertase 1 deficiency.
References in periodicals archive ?
Another potential convertase is the prohormone convertase 1 (PC1), which exists in atrial myocytes and maycleave proANP (28), but it is unknown whether PC1 circulates or whether it may process proBNP.
She has a mutant gene for prohormone convertase 1, an enzyme that activates certain proteins, including insulin, as the final step in their production.