Progestins


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Related to Progestins: Progestogens

Progestins

A female hormone, like progesterone, that acts on the inner lining of the uterus.
References in periodicals archive ?
The company will start its Phase 2 clinical study of Virexxa in conjunction with progestin therapy for the treatment of endometrial cancer in women with recurrent or persistent disease who have failed progestin monotherapy.
The combined oral contraceptive pills containing third- (and fourth-) generation progestins (e.
Treatment results of endometrial hyperplasia after prospective D-score classification: A follow-up study comparing effect of LNG-IUD and oral progestins versus observation only.
Progestins are also used alone for birth control and for treatment of a variety of other conditions, including abnormal uterine bleeding and amenorrhea (absence of periods); endometriosis; breast, kidney or uterine cancer; and loss of appetite and weight related to AIDS and cancer.
They combined a transdermal (skin) gel containing the male hormone testosterone and a gel containing a new synthetic progestin called Nestorone.
For example, the Yasmin label now includes the statement that based on the currently available information, "DRSP [drospirenone]-containing COCs may be associated with a higher risk of venous thromboembolism (VTE) than COCs containing the progestin levonorgestrel or some other progestins.
The team, led by the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) in Vienna, in collaboration with scientists based at institutions including University College London, demonstrated that progestin can also trigger the rankl protein in breast cells in mice.
These are mostly low-grade adenocarcinomas with a good prognosis and well-described risk factors such as nulliparity, obesity, hyperoestrogenism, other cancers, tamoxifen use and inadequate progestin cover when taking oestrogens.
Maintaining menstrual cycles, a function of progestins, is important during childbearing years because shedding the uterine lining each month reduces the risk of endometrial cancer.
The first such product to contain drospirenone, a synthetic progestin and spironolactone analog with antimineralocorticoid activity.
Here's the reality behind the WHI: Basically, in 2002 the WHI found that women taking the hormone therapy Prempro, composed of progestin (a synthetic progestogen known as medroxyprogesterone acetate or MPA) and conjugated equine estrogen, had a 26 percent increased risk of invasive breast cancer, a 29 percent increased risk of heart attack, a 41 percent higher rate of stroke and more than a 100 percent increase in blood clots in the lung.
The FDA recommends that estrogens and progestins should be used at the lowest doses for the shortest duration needed to achieve treatment goals.

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